Open Access

Pharmaceutics, volume 14, issue 7, pages 1355

Effect of Exo/Endogenous Prophylaxis Dentifrice/Drug and Cariogenic Conditions of Patient on Molecular Property of Dental Biofilm: Synchrotron FTIR Spectroscopic Study

Seredin Pavel V. ^{1, 2}

Goloshchapov Dmitry ¹

Kashkarov Vladimir ¹

Nesterov Dmitry ¹

Ippolitov Yuri ³

Ippolitov Ivan ³

Vongsvivut Jitraporn ⁴

Hide authors affiliations Show authors affiliations: 4 affiliations

Department of Solid-State Physics and Nanostructures, Voronezh State University, 394018 Voronezh, Russia |

Scientific and Educational Center “Nanomaterials and Nanotechnologies”, Ural Federal University, 19 Mira Street, 620002 Ekaterinburg, Russia |

Department of Pediatric Dentistry with Orthodontia, Voronezh State Medical University, 394006 Voronezh, Russia |

⁴

Australian Synchrotron, Clayton, VIC 3168, Australia |

Publication type: Journal Article

Publication date: 2022-06-26

Multidisciplinary Digital Publishing Institute (MDPI)

Journal: Pharmaceutics

Quartile SCImago

Quartile WOS

Impact factor: 5.4

ISSN: 19994923

DOI: 10.3390/pharmaceutics14071355

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Pharmaceutical Science

Abstract

(1) Objectives: This study is the first one to investigate the molecular composition of the dental biofilm during the exogenous and endogenous prophylaxis stages (use of dentifrice/drug) of individuals with different cariogenic conditions using molecular spectroscopy methods. (2) Materials and Methods: The study involved 100 participants (50 males and 50 females), aged 18–25 years with different caries conditions. Biofilm samples were collected from the teeth surface of all participants. The molecular composition of biofilms was investigated using synchrotron infrared microspectroscopy. Changes in the molecular composition were studied through calculation and analysis of ratios between organic and mineral components of biofilm samples. (3) Results: Based on the data obtained by synchrotron FTIR, calculations of organic and mineral component ratios, and statistical analysis of the data, we were able to assess changes occurring in the molecular composition of the dental biofilm. Variations in the phosphate/protein/lipid, phosphate/mineral, and phospholipid/lipid ratios and the presence of statistically significant intra- and inter-group differences in these ratios indicate that the mechanisms of ion adsorption, compounds and complexes arriving from oral fluid into dental biofilm during exo/endogenous prophylaxis, differ for patients in norm and caries development. (4) Conclusions: The conformational environment and charge interaction in the microbiota and the electrostatic state of the biofilm protein network in patients with different cariogenic conditions play an important role. (5) Clinical Significance: Understanding the changes that occur in the molecular composition of the dental biofilm in different oral homeostasis conditions will enable successful transition to a personalised approach in dentistry and high-tech healthcare.

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Citations by journals

	1
Dentistry Journal	Dentistry Journal, 1, 25% Dentistry Journal 1 publication, 25%
The actual problems in dentistry	The actual problems in dentistry, 1, 25% The actual problems in dentistry 1 publication, 25%
Photonics	Photonics, 1, 25% Photonics 1 publication, 25%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 25% International Journal of Molecular Sciences 1 publication, 25%
	1

Citations by publishers

	1 2
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 2, 50% Multidisciplinary Digital Publishing Institute (MDPI) 2 publications, 50%
TIRAZH Publishing House	TIRAZH Publishing House, 1, 25% TIRAZH Publishing House 1 publication, 25%
	1 2

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Seredin P. V. et al. Effect of Exo/Endogenous Prophylaxis Dentifrice/Drug and Cariogenic Conditions of Patient on Molecular Property of Dental Biofilm: Synchrotron FTIR Spectroscopic Study // Pharmaceutics. 2022. Vol. 14. No. 7. p. 1355.

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Seredin P. V., Goloshchapov D., Kashkarov V., Nesterov D., Ippolitov Y., Ippolitov I., Vongsvivut J. Effect of Exo/Endogenous Prophylaxis Dentifrice/Drug and Cariogenic Conditions of Patient on Molecular Property of Dental Biofilm: Synchrotron FTIR Spectroscopic Study // Pharmaceutics. 2022. Vol. 14. No. 7. p. 1355.

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TY - JOUR

DO - 10.3390/pharmaceutics14071355

UR - https://doi.org/10.3390%2Fpharmaceutics14071355

TI - Effect of Exo/Endogenous Prophylaxis Dentifrice/Drug and Cariogenic Conditions of Patient on Molecular Property of Dental Biofilm: Synchrotron FTIR Spectroscopic Study

T2 - Pharmaceutics

AU - Goloshchapov, Dmitry

AU - Nesterov, Dmitry

AU - Kashkarov, Vladimir

AU - Ippolitov, Yuri

AU - Ippolitov, Ivan

AU - Seredin, Pavel V.

AU - Vongsvivut, Jitraporn

PY - 2022

DA - 2022/06/26 00:00:00

PB - Multidisciplinary Digital Publishing Institute (MDPI)

SP - 1355

IS - 7

VL - 14

SN - 1999-4923

ER -

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@article{2022_Seredin,

author = {Dmitry Goloshchapov and Dmitry Nesterov and Vladimir Kashkarov and Yuri Ippolitov and Ivan Ippolitov and Pavel V. Seredin and Jitraporn Vongsvivut},

title = {Effect of Exo/Endogenous Prophylaxis Dentifrice/Drug and Cariogenic Conditions of Patient on Molecular Property of Dental Biofilm: Synchrotron FTIR Spectroscopic Study},

journal = {Pharmaceutics},

year = {2022},

volume = {14},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

month = {jun},

url = {https://doi.org/10.3390%2Fpharmaceutics14071355},

number = {7},

pages = {1355},

doi = {10.3390/pharmaceutics14071355}

}

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Seredin, Pavel V., et al. “Effect of Exo/Endogenous Prophylaxis Dentifrice/Drug and Cariogenic Conditions of Patient on Molecular Property of Dental Biofilm: Synchrotron FTIR Spectroscopic Study.” Pharmaceutics, vol. 14, no. 7, Jun. 2022, p. 1355. https://doi.org/10.3390%2Fpharmaceutics14071355.

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Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

Journal

Pharmaceutics

Quartile SCImago

Quartile WOS

Impact factor

5.4

ISSN

19994923 (Print)

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Бактерии на больных зубах снизили эффективность средств для профилактики кариеса