Open Access
Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review
Cláudia Viegas
1, 2, 3, 4
,
Ana B. Patrício
3, 4
,
João M. Prata
3, 4
,
Akhtar Nadhman
5
,
Pavan Kumar Chintamaneni
6
,
P. Fonte
1, 3, 4, 7
1
5
Institute of Integrative Biosciences, CECOS University, Hayatabad, Peshawar 25000, Pakistan
|
Publication type: Journal Article
Publication date: 2023-05-25
PubMed ID:
37376042
Pharmaceutical Science
Abstract
Solid–lipid nanoparticles and nanostructured lipid carriers are delivery systems for the delivery of drugs and other bioactives used in diagnosis, therapy, and treatment procedures. These nanocarriers may enhance the solubility and permeability of drugs, increase their bioavailability, and extend the residence time in the body, combining low toxicity with a targeted delivery. Nanostructured lipid carriers are the second generation of lipid nanoparticles differing from solid lipid nanoparticles in their composition matrix. The use of a liquid lipid together with a solid lipid in nanostructured lipid carrier allows it to load a higher amount of drug, enhance drug release properties, and increase its stability. Therefore, a direct comparison between solid lipid nanoparticles and nanostructured lipid carriers is needed. This review aims to describe solid lipid nanoparticles and nanostructured lipid carriers as drug delivery systems, comparing both, while systematically elucidating their production methodologies, physicochemical characterization, and in vitro and in vivo performance. In addition, the toxicity concerns of these systems are focused on.
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Total citations:
274
Citations from 2024:
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(92.64%)
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GOST
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Viegas C. et al. Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review // Pharmaceutics. 2023. Vol. 15. No. 6. p. 1593.
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Viegas C., Patrício A. B., Prata J. M., Nadhman A., Chintamaneni P. K., Fonte P. Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review // Pharmaceutics. 2023. Vol. 15. No. 6. p. 1593.
Cite this
RIS
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TY - JOUR
DO - 10.3390/pharmaceutics15061593
UR - https://doi.org/10.3390/pharmaceutics15061593
TI - Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review
T2 - Pharmaceutics
AU - Viegas, Cláudia
AU - Patrício, Ana B.
AU - Prata, João M.
AU - Nadhman, Akhtar
AU - Chintamaneni, Pavan Kumar
AU - Fonte, P.
PY - 2023
DA - 2023/05/25
PB - MDPI
SP - 1593
IS - 6
VL - 15
PMID - 37376042
SN - 1999-4923
ER -
Cite this
BibTex (up to 50 authors)
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@article{2023_Viegas,
author = {Cláudia Viegas and Ana B. Patrício and João M. Prata and Akhtar Nadhman and Pavan Kumar Chintamaneni and P. Fonte},
title = {Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review},
journal = {Pharmaceutics},
year = {2023},
volume = {15},
publisher = {MDPI},
month = {may},
url = {https://doi.org/10.3390/pharmaceutics15061593},
number = {6},
pages = {1593},
doi = {10.3390/pharmaceutics15061593}
}
Cite this
MLA
Copy
Viegas, Cláudia, et al. “Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review.” Pharmaceutics, vol. 15, no. 6, May. 2023, p. 1593. https://doi.org/10.3390/pharmaceutics15061593.