Open Access
Pluronic F127-Folate Coated Super Paramagenic Iron Oxide Nanoparticles as Contrast Agent for Cancer Diagnosis in Magnetic Resonance Imaging
Quang Hieu Vu
1, 2, 3
,
Mads Sloth Vinding
3
,
Thomas Nielsen
3
,
Marcus Görge Ullisch
3
,
Niels Chr. Nielsen
3
,
Dinh Truong Nguyen
2
,
Jørgen Kjems
3, 4
2
School of Biotechnology, Tan Tao University, Long An 82000, Vietnam
|
Publication type: Journal Article
Publication date: 2019-04-25
PubMed ID:
31027171
General Chemistry
Polymers and Plastics
Abstract
Contrast agents have been widely used in medicine to enhance contrast in magnetic resonance imaging (MRI). Among them, super paramagnetic iron oxide nanoparticles (SPION) have been reported to have low risk in clinical use. In our study, F127-Folate coated SPION was fabricated in order to efficiently target tumors and provide imaging contrast in MRI. SPION alone have an average core size of 15 nm. After stabilizing with Pluronic F127, the nanoparticles reached a hydrodynamic size of 180 nm and dispersed well in various kinds of media. The F127-Folate coated SPION were shown to specifically target folate receptor expressing cancer cells by flow cytometry analysis, confocal laser scanning microscope, as well as in vitro MRI. Furthermore, in vivo MRI images have shown the enhanced negative contrast from the F127-Folate coated SPION in tumor-bearing mice. In conclusion, our F127-Folate coated SPION have shown great potential as a contrast agent in MRI, as well as in the combination with drug delivery for cancer therapy.
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Metrics
54
Total citations:
54
Citations from 2024:
14
(25.92%)
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GOST
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Vu Q. H. et al. Pluronic F127-Folate Coated Super Paramagenic Iron Oxide Nanoparticles as Contrast Agent for Cancer Diagnosis in Magnetic Resonance Imaging // Polymers. 2019. Vol. 11. No. 4. p. 743.
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Vu Q. H., Vinding M. S., Nielsen T., Ullisch M. G., Nielsen N., Nguyen D. T., Kjems J. Pluronic F127-Folate Coated Super Paramagenic Iron Oxide Nanoparticles as Contrast Agent for Cancer Diagnosis in Magnetic Resonance Imaging // Polymers. 2019. Vol. 11. No. 4. p. 743.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/polym11040743
UR - https://doi.org/10.3390/polym11040743
TI - Pluronic F127-Folate Coated Super Paramagenic Iron Oxide Nanoparticles as Contrast Agent for Cancer Diagnosis in Magnetic Resonance Imaging
T2 - Polymers
AU - Vu, Quang Hieu
AU - Vinding, Mads Sloth
AU - Nielsen, Thomas
AU - Ullisch, Marcus Görge
AU - Nielsen, Niels Chr.
AU - Nguyen, Dinh Truong
AU - Kjems, Jørgen
PY - 2019
DA - 2019/04/25
PB - MDPI
SP - 743
IS - 4
VL - 11
PMID - 31027171
SN - 2073-4360
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Vu,
author = {Quang Hieu Vu and Mads Sloth Vinding and Thomas Nielsen and Marcus Görge Ullisch and Niels Chr. Nielsen and Dinh Truong Nguyen and Jørgen Kjems},
title = {Pluronic F127-Folate Coated Super Paramagenic Iron Oxide Nanoparticles as Contrast Agent for Cancer Diagnosis in Magnetic Resonance Imaging},
journal = {Polymers},
year = {2019},
volume = {11},
publisher = {MDPI},
month = {apr},
url = {https://doi.org/10.3390/polym11040743},
number = {4},
pages = {743},
doi = {10.3390/polym11040743}
}
Cite this
MLA
Copy
Vu, Quang Hieu, et al. “Pluronic F127-Folate Coated Super Paramagenic Iron Oxide Nanoparticles as Contrast Agent for Cancer Diagnosis in Magnetic Resonance Imaging.” Polymers, vol. 11, no. 4, Apr. 2019, p. 743. https://doi.org/10.3390/polym11040743.