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Processes

, том 10 , издание 2 , страницы 383

Human Cytochrome P450 2C9 and Its Polymorphic Modifications: Electroanalysis, Catalytic Properties, and Approaches to the Regulation of Enzymatic Activity

Victoria V Shumyantseva ^{1, 2}

Tatiana V. Bulko ¹

Polina I Koroleva ¹

Evgeniya V Shikh ³

Anna A Makhova ³

Maryia S Kisel ⁴

Irina V Haidukevich ⁴

Andrei A. Gilep ^{1, 4}

Скрыть аффилиации авторов Показать аффилиации авторов: 4 аффилиации

Institute of Biomedical Chemistry, Pogodinskaya Street, 10, Build 8, 119121 Moscow, Russia |

Faculty of Biomedicine, Pirogov Russian National Research Medical University, Ostrovitianov Street, 1, 117997 Moscow, Russia |

Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, I.M. Sechenov First Moscow Medical State University (Sechenov University), Trubetskaya Str., 8/2, 119991 Moscow, Russia |

⁴

Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, 220141 Minsk, Belarus |

Тип публикации: Journal Article

Дата публикации: 2022-02-17

MDPI

Processes

scimago Q2

wos Q3

БС2

SJR: 0.554

CiteScore: 5.5

Impact factor: 2.8

ISSN: 22279717

DOI: 10.3390/pr10020383

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Process Chemistry and Technology

Bioengineering

Chemical Engineering (miscellaneous)

Краткое описание

The electrochemical properties of cytochrome P450 2C9 (CYP2C9) and polymorphic modifications P450 2C9*2 (CYP2C9*2) and P450 2C9*3 (CYP2C9*3) were studied. To analyze the comparative electrochemical and electrocatalytic activity, the enzymes were immobilized on electrodes modified with a membrane-like synthetic surfactant (didodecyldimethylammonium bromide (DDAB)). An adequate choice of the type of modified electrode was confirmed by cyclic voltammetry of cytochromes P450 under anaerobic conditions, demonstrating well-defined peaks of reduction and oxidation of the heme iron. The midpoint potential, Emid, of cytochrome P450 2C9 is −0.318 ± 0.01 V, and Emid = −0.324 ± 0.01 V, and Emid = −0.318 ± 0.03 V for allelic variant 2C9*2 and allelic variant 2C9*3, respectively. In the presence of substrate diclofenac under aerobic conditions, cytochrome P450 2C9 and its polymorphic modifications P450 2C9*2 and P450 2C9*3 exhibit catalytic properties. Stimulation of the metabolism of diclofenac by cytochrome P450 2C9 in the presence of antioxidant medications mexidol and taurine was shown.

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Московский государственный университет имени М.В. Ломоносова

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Московский государственный университет имени М.В. Ломоносова

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Полимеры для доставки лекарств

Системы доставки лекарственных веществ

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Shumyantseva V. V. et al. Human Cytochrome P450 2C9 and Its Polymorphic Modifications: Electroanalysis, Catalytic Properties, and Approaches to the Regulation of Enzymatic Activity // Processes. 2022. Vol. 10. No. 2. p. 383.

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Shumyantseva V. V., Bulko T. V., Koroleva P. I., Shikh E. V., Makhova A. A., Kisel M. S., Haidukevich I. V., Gilep A. A. Human Cytochrome P450 2C9 and Its Polymorphic Modifications: Electroanalysis, Catalytic Properties, and Approaches to the Regulation of Enzymatic Activity // Processes. 2022. Vol. 10. No. 2. p. 383.

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TY - JOUR

DO - 10.3390/pr10020383

UR - https://doi.org/10.3390/pr10020383

TI - Human Cytochrome P450 2C9 and Its Polymorphic Modifications: Electroanalysis, Catalytic Properties, and Approaches to the Regulation of Enzymatic Activity

T2 - Processes

AU - Shumyantseva, Victoria V

AU - Bulko, Tatiana V.

AU - Koroleva, Polina I

AU - Shikh, Evgeniya V

AU - Makhova, Anna A

AU - Kisel, Maryia S

AU - Haidukevich, Irina V

AU - Gilep, Andrei A.

PY - 2022

DA - 2022/02/17

PB - MDPI

SP - 383

IS - 2

VL - 10

SN - 2227-9717

ER -

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@article{2022_Shumyantseva,

author = {Victoria V Shumyantseva and Tatiana V. Bulko and Polina I Koroleva and Evgeniya V Shikh and Anna A Makhova and Maryia S Kisel and Irina V Haidukevich and Andrei A. Gilep},

title = {Human Cytochrome P450 2C9 and Its Polymorphic Modifications: Electroanalysis, Catalytic Properties, and Approaches to the Regulation of Enzymatic Activity},

journal = {Processes},

year = {2022},

volume = {10},

publisher = {MDPI},

month = {feb},

url = {https://doi.org/10.3390/pr10020383},

number = {2},

pages = {383},

doi = {10.3390/pr10020383}

}

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Shumyantseva, Victoria V., et al. “Human Cytochrome P450 2C9 and Its Polymorphic Modifications: Electroanalysis, Catalytic Properties, and Approaches to the Regulation of Enzymatic Activity.” Processes, vol. 10, no. 2, Feb. 2022, p. 383. https://doi.org/10.3390/pr10020383.

Издатель

MDPI

Журнал

Processes

scimago Q2

wos Q3

БС2

SJR

0.554

CiteScore

5.5

Impact factor

2.8

ISSN

22279717 (Electronic)