Open Access
Sensors, volume 22, issue 1, pages 161
Advances in Design Strategies of Multiplex Electrochemical Aptasensors
1
Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland
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2
Department of Chemistry, State University of New York at Potsdam, Potsdam, NY 13676, USA
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Publication type: Journal Article
Publication date: 2021-12-27
Biochemistry
Analytical Chemistry
Atomic and Molecular Physics, and Optics
Electrical and Electronic Engineering
Instrumentation
Abstract
In recent years, the need for simple, fast, and economical detection of food and environmental contaminants, and the necessity to monitor biomarkers of different diseases have considerably accelerated the development of biosensor technology. However, designing biosensors capable of simultaneous determination of two or more analytes in a single measurement, for example on a single working electrode in single solution, is still a great challenge. On the other hand, such analysis offers many advantages compared to single analyte tests, such as cost per test, labor, throughput, and convenience. Because of the high sensitivity and scalability of the electrochemical detection systems on the one hand and the specificity of aptamers on the other, the electrochemical aptasensors are considered to be highly effective devices for simultaneous detection of multiple-target analytes. In this review, we describe and evaluate multi-label approaches based on (1) metal quantum dots and metal ions, (2) redox labels, and (3) enzyme labels. We focus on recently developed strategies for multiplex sensing using electrochemical aptasensors. Furthermore, we emphasize the use of different nanomaterials in the construction of these aptasensors. Based on examples from the existing literature, we highlight recent applications of multiplexed detection platforms in clinical diagnostics, food control, and environmental monitoring. Finally, we discuss the advantages and disadvantages of the aptasensors developed so far, and debate possible challenges and prospects.
Top-30
Citations by journals
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International Journal of Molecular Sciences
2 publications, 10.53%
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Sensors
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TrAC - Trends in Analytical Chemistry
2 publications, 10.53%
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Microchimica Acta
1 publication, 5.26%
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Sensors & Diagnostics
1 publication, 5.26%
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Biosensors
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Annual Review of Analytical Chemistry
1 publication, 5.26%
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Journal of Micromechanics and Microengineering
1 publication, 5.26%
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Biosensors and Bioelectronics: X
1 publication, 5.26%
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Biosensors and Bioelectronics
1 publication, 5.26%
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Russian Chemical Reviews
1 publication, 5.26%
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ACS Omega
1 publication, 5.26%
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Talanta
1 publication, 5.26%
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Citations by publishers
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7
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Multidisciplinary Digital Publishing Institute (MDPI)
7 publications, 36.84%
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Elsevier
6 publications, 31.58%
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Springer Nature
1 publication, 5.26%
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Royal Society of Chemistry (RSC)
1 publication, 5.26%
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Annual Reviews
1 publication, 5.26%
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IOP Publishing
1 publication, 5.26%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 5.26%
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American Chemical Society (ACS)
1 publication, 5.26%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Grabowska I., Hepel M., Kurzątkowska K. Advances in Design Strategies of Multiplex Electrochemical Aptasensors // Sensors. 2021. Vol. 22. No. 1. p. 161.
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Grabowska I., Hepel M., Kurzątkowska K. Advances in Design Strategies of Multiplex Electrochemical Aptasensors // Sensors. 2021. Vol. 22. No. 1. p. 161.
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TY - JOUR
DO - 10.3390/s22010161
UR - https://doi.org/10.3390/s22010161
TI - Advances in Design Strategies of Multiplex Electrochemical Aptasensors
T2 - Sensors
AU - Hepel, Maria
AU - Grabowska, Iwona
AU - Kurzątkowska, Katarzyna
PY - 2021
DA - 2021/12/27 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 161
IS - 1
VL - 22
SN - 1424-3210
SN - 1424-8220
ER -
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@article{2021_Grabowska,
author = {Maria Hepel and Iwona Grabowska and Katarzyna Kurzątkowska},
title = {Advances in Design Strategies of Multiplex Electrochemical Aptasensors},
journal = {Sensors},
year = {2021},
volume = {22},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {dec},
url = {https://doi.org/10.3390/s22010161},
number = {1},
pages = {161},
doi = {10.3390/s22010161}
}
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Grabowska, Iwona, et al. “Advances in Design Strategies of Multiplex Electrochemical Aptasensors.” Sensors, vol. 22, no. 1, Dec. 2021, p. 161. https://doi.org/10.3390/s22010161.