volume 1, issue 1, pages 3-32

Heterologous Production of Acrylic Acid: Current Challenges and Perspectives

Joana Ramos Rodrigues ^{1, 2}

Hide authors affiliations Show authors affiliations: 2 affiliations

CEB–Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal |

LABBELS–Associate Laboratory, 4710-057 Braga, Portugal |

Publication type: Journal Article

Publication date: 2022-05-30

—

DOI: 10.3390/synbio1010002

Copy DOI

Abstract

Acrylic acid (AA) is a chemical with high market value used in industry to produce diapers, paints, adhesives and coatings, among others. AA available worldwide is chemically produced mostly from petroleum derivatives. Due to its economic relevance, there is presently a need for innovative and sustainable ways to synthesize AA. In the past decade, several semi-biological methods have been developed and consist in the bio-based synthesis of 3-hydroxypropionic acid (3-HP) and its chemical conversion to AA. However, more recently, engineered Escherichia coli was demonstrated to be able to convert glucose or glycerol to AA. Several pathways have been developed that use as precursors glycerol, malonyl-CoA or β-alanine. Some of these pathways produce 3-HP as an intermediate. Nevertheless, the heterologous production of AA is still in its early stages compared, for example, to 3-HP production. So far, only up to 237 mg/L of AA have been produced from glucose using β-alanine as a precursor in fed-batch fermentation. In this review, the advances in the production of AA by engineered microbes, as well as the hurdles hindering high-level production, are discussed. In addition, synthetic biology and metabolic engineering approaches to improving the production of AA in industrial settings are presented.

By date By citations

Top-30

Journals

	1
Molecules	Molecules, 1, 7.69% Molecules 1 publication, 7.69%
Macromolecules	Macromolecules, 1, 7.69% Macromolecules 1 publication, 7.69%
Journal of Flow Chemistry	Journal of Flow Chemistry, 1, 7.69% Journal of Flow Chemistry 1 publication, 7.69%
Topics in Catalysis	Topics in Catalysis, 1, 7.69% Topics in Catalysis 1 publication, 7.69%
Chemical Engineering Research and Design	Chemical Engineering Research and Design, 1, 7.69% Chemical Engineering Research and Design 1 publication, 7.69%
Reaction Chemistry and Engineering	Reaction Chemistry and Engineering, 1, 7.69% Reaction Chemistry and Engineering 1 publication, 7.69%
SynBio	SynBio, 1, 7.69% SynBio 1 publication, 7.69%
ACS Sustainable Chemistry and Engineering	ACS Sustainable Chemistry and Engineering, 1, 7.69% ACS Sustainable Chemistry and Engineering 1 publication, 7.69%
Chemical Engineering Communications	Chemical Engineering Communications, 1, 7.69% Chemical Engineering Communications 1 publication, 7.69%
Process Safety and Environmental Protection	Process Safety and Environmental Protection, 1, 7.69% Process Safety and Environmental Protection 1 publication, 7.69%
Synthetic and Systems Biotechnology	Synthetic and Systems Biotechnology, 1, 7.69% Synthetic and Systems Biotechnology 1 publication, 7.69%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 7.69% Russian Chemical Reviews 1 publication, 7.69%
Waste and Biomass Valorization	Waste and Biomass Valorization, 1, 7.69% Waste and Biomass Valorization 1 publication, 7.69%
	1

Publishers

	1 2
MDPI	MDPI, 2, 15.38% MDPI 2 publications, 15.38%
American Chemical Society (ACS)	American Chemical Society (ACS), 2, 15.38% American Chemical Society (ACS) 2 publications, 15.38%
Springer Nature	Springer Nature, 2, 15.38% Springer Nature 2 publications, 15.38%
Elsevier	Elsevier, 2, 15.38% Elsevier 2 publications, 15.38%
Akademiai Kiado	Akademiai Kiado, 1, 7.69% Akademiai Kiado 1 publication, 7.69%
Institution of Chemical Engineers	Institution of Chemical Engineers, 1, 7.69% Institution of Chemical Engineers 1 publication, 7.69%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 7.69% Royal Society of Chemistry (RSC) 1 publication, 7.69%
Taylor & Francis	Taylor & Francis, 1, 7.69% Taylor & Francis 1 publication, 7.69%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 7.69% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 7.69%
	1 2

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Publication PDF

Metrics

Found error?

Publisher

—