Open Access
Design and Immunological Properties of the Novel Subunit Virus-like Vaccine against SARS-CoV-2
Igor V Krasilnikov
1
,
Aleksandr V Kudriavtsev
2
,
Maria E Frolova
3
,
Aleksandr Ivanov
4
,
Marina A Stukova
1
,
Ekaterina A. Romanovskaya-Romanko
1
,
Nataliya V Mushenkova
2
,
Artur A. Isaev
3, 5
2
Betuvax, 121096 Moscow, Russia
|
3
PJSC Human Stem Cells Institute, 129110 Moscow, Russia
|
4
Razvitie BioTechnologiy, 119136 Moscow, Russia
|
5
Center of Genetics and Reproductive Medicine “Genetico”, 119333 Moscow, Russia
|
Publication type: Journal Article
Publication date: 2022-01-02
PubMed ID:
35062730
Drug Discovery
Pharmacology
Infectious Diseases
Pharmacology (medical)
Immunology
Abstract
The COVID-19 pandemic is ongoing, and the need for safe and effective vaccines to prevent infection and to control spread of the virus remains urgent. Here, we report the development of a SARS-CoV-2 subunit vaccine candidate (Betuvax-CoV-2) based on RBD and SD1 domains of the spike (S) protein fused to a human IgG1 Fc fragment. The antigen is adsorbed on betulin adjuvant, forming spherical particles with a size of 100–180 nm, mimicking the size of viral particles. Here we confirm the potent immunostimulatory activity of betulin adjuvant, and demonstrate that two immunizations of mice with Betuvax-CoV-2 elicited high titers of RBD-specific antibodies. The candidate vaccine was also effective in stimulating a neutralizing antibody response and T cell immunity. The results indicate that Betuvax-CoV-2 has good potential for further development as an effective vaccine against SARS-CoV-2.
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11
Total citations:
11
Citations from 2025:
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GOST
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Krasilnikov I. V. et al. Design and Immunological Properties of the Novel Subunit Virus-like Vaccine against SARS-CoV-2 // Vaccines. 2022. Vol. 10. No. 1. p. 69.
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Krasilnikov I. V., Kudriavtsev A. V., Vakhrusheva A. V., Frolova M. E., Ivanov A., Stukova M. A., Romanovskaya-Romanko E. A., Vasiliev K. A., Mushenkova N. V., Isaev A. A. Design and Immunological Properties of the Novel Subunit Virus-like Vaccine against SARS-CoV-2 // Vaccines. 2022. Vol. 10. No. 1. p. 69.
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RIS
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TY - JOUR
DO - 10.3390/vaccines10010069
UR - https://doi.org/10.3390/vaccines10010069
TI - Design and Immunological Properties of the Novel Subunit Virus-like Vaccine against SARS-CoV-2
T2 - Vaccines
AU - Krasilnikov, Igor V
AU - Kudriavtsev, Aleksandr V
AU - Vakhrusheva, Anna V
AU - Frolova, Maria E
AU - Ivanov, Aleksandr
AU - Stukova, Marina A
AU - Romanovskaya-Romanko, Ekaterina A.
AU - Vasiliev, Kirill A
AU - Mushenkova, Nataliya V
AU - Isaev, Artur A.
PY - 2022
DA - 2022/01/02
PB - MDPI
SP - 69
IS - 1
VL - 10
PMID - 35062730
SN - 2076-393X
ER -
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BibTex (up to 50 authors)
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@article{2022_Krasilnikov,
author = {Igor V Krasilnikov and Aleksandr V Kudriavtsev and Anna V Vakhrusheva and Maria E Frolova and Aleksandr Ivanov and Marina A Stukova and Ekaterina A. Romanovskaya-Romanko and Kirill A Vasiliev and Nataliya V Mushenkova and Artur A. Isaev},
title = {Design and Immunological Properties of the Novel Subunit Virus-like Vaccine against SARS-CoV-2},
journal = {Vaccines},
year = {2022},
volume = {10},
publisher = {MDPI},
month = {jan},
url = {https://doi.org/10.3390/vaccines10010069},
number = {1},
pages = {69},
doi = {10.3390/vaccines10010069}
}
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MLA
Copy
Krasilnikov, Igor V., et al. “Design and Immunological Properties of the Novel Subunit Virus-like Vaccine against SARS-CoV-2.” Vaccines, vol. 10, no. 1, Jan. 2022, p. 69. https://doi.org/10.3390/vaccines10010069.