Carcinogenic hazard of "non-carcinogenic" compounds

Due to the high rates of industrialization, the biosphere is increasingly polluted by both complete carcinogens and compounds that are not able to induce a tumor on their own, but, as it turned out recently, cause changes in the cell corresponding to particular links in the chain of carcinogenesis. Some of these compounds are of great economic interest, and therefore an international agreement allows their unlimited production. At the same time, when combined, these "semi-carcinogens" can either cause malignant transformation or stimulate the action of ubiquitously widespread carcinogens. The saturation of the biosphere with such xenobiotics may be one of the universal factors of the observed increase in cancer incidence. In this regard, the practice of assessing the carcinogenic hazard of chemical compounds based on mechanistic signs should be changed, since it does not take into account the effect of the carcinogenic background of the environment. In vitro experiments should be carried out not only in standard purified media, but also with the addition of the sum of the main components of biospheric pollution in concentrations found, for example, in blood from the umbilical cord of newborns and breast milk. Such additives need to be created and standardized as is customary for Reference materials.