Cancer stem cells and hypoxia-inducible factors (Review)
Тип публикации: Journal Article
Дата публикации: 2018-05-22
scimago Q2
wos Q1
white level БС1
SJR: 1.226
CiteScore: 8.9
Impact factor: 4.9
ISSN: 10196439, 17912423
PubMed ID:
29845228
Cancer Research
Oncology
Краткое описание
Cancer stem cells (CSCs), also known as tumor-initiating cells, are a subpopulation of tumor cells that exhibit properties similar to those of normal stem cells. Oxygen is an important regulator of cellular metabolism; hypoxia-inducible factors (HIFs) mediate metabolic switches in cells in hypoxic environments. Hypoxia clearly has the potential to exert a significant effect on the maintenance and evolution of CSCs. Both HIF‑1α and HIF‑2α may contribute to the regulation of cellular adaptation to hypoxia and resistance to cancer therapies. This review provides an overview of the roles of HIFs in CSCs. HIF‑1α and HIF‑2α have significant prognostic and predictive value in the clinic and the concept of personalized medicine should be applied in designing clinical trials for HIF inhibitors.
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ГОСТ
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TONG W., TONG G., Liu Y. G. Cancer stem cells and hypoxia-inducible factors (Review) // International Journal of Oncology. 2018. Vol. 53. No. 2.
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TONG W., TONG G., Liu Y. G. Cancer stem cells and hypoxia-inducible factors (Review) // International Journal of Oncology. 2018. Vol. 53. No. 2.
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TY - JOUR
DO - 10.3892/ijo.2018.4417
UR - https://doi.org/10.3892/ijo.2018.4417
TI - Cancer stem cells and hypoxia-inducible factors (Review)
T2 - International Journal of Oncology
AU - TONG, WEI-WEI
AU - TONG, GUANG-HUI
AU - Liu, Yong Gang
PY - 2018
DA - 2018/05/22
PB - Spandidos Publications
IS - 2
VL - 53
PMID - 29845228
SN - 1019-6439
SN - 1791-2423
ER -
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BibTex (до 50 авторов)
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@article{2018_TONG,
author = {WEI-WEI TONG and GUANG-HUI TONG and Yong Gang Liu},
title = {Cancer stem cells and hypoxia-inducible factors (Review)},
journal = {International Journal of Oncology},
year = {2018},
volume = {53},
publisher = {Spandidos Publications},
month = {may},
url = {https://doi.org/10.3892/ijo.2018.4417},
number = {2},
doi = {10.3892/ijo.2018.4417}
}
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