Recombinant protein TRAIL-Mu3 enhances the antitumor effects in pancreatic cancer cells by strengthening the apoptotic signaling pathway
Min Huang
1
,
Cheng Yi
2
,
Xian-Zhou Huang
3
,
Juan Yan
3
,
Li-Jia Wei
3
,
Wei-Ju Tang
4
,
Shou-Chun Chen
3
,
Ying Huang
5
3
Chengdu Huachuang Biotechnology Co., Ltd., Chengdu, Sichuan 610000, P.R. China
|
4
Department of Neurology, The First People's Hospital of Longquanyi District, Chengdu, Sichuan 610000, P.R. China
|
Publication type: Journal Article
Publication date: 2021-04-01
scimago Q3
wos Q3
SJR: 0.663
CiteScore: 4.6
Impact factor: 2.2
ISSN: 17921074, 17921082
PubMed ID:
33868476
Cancer Research
Oncology
Abstract
Pancreatic cancer is a highly malignant type of cancer and its treatment remains a major challenge. The novel recombinant protein TNF-related apoptosis-inducing ligand (TRAIL)-Mu3 has been shown to exert stronger tumor inhibitory effects in colon cancer in vitro and in vivo compared with TRAIL. The present study investigated the antitumor effects of TRAIL-Mu3 on pancreatic cancer cells, and the possible mechanisms were further examined. Compared with TRAIL, TRAIL-Mu3 exhibited significantly higher cytotoxic effects on pancreatic cancer cell lines. The inhibitory effect of TRAIL-Mu3 on the viability of PANC-1 cells was shown to be a caspase-dependent process. The affinity of TRAIL-Mu3 to PANC-1 cell membranes was significantly enhanced compared with TRAIL. In addition, TRAIL-Mu3 upregulated death receptor (DR) expression in PANC-1 cells and promoted the redistribution of DR5 in lipid rafts. Western blotting results demonstrated that TRAIL-Mu3 activated the caspase cascade in a faster and more efficient manner compared with TRAIL in PANC-1 cells. Therefore, TRAIL-Mu3 enhanced the antitumor effects in pancreatic cancer cells by strengthening the apoptotic signaling pathway. The present study indicated the potential of TRAIL-Mu3 for the treatment of pancreatic cancer.
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Total citations:
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Citations from 2024:
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Huang M. et al. Recombinant protein TRAIL-Mu3 enhances the antitumor effects in pancreatic cancer cells by strengthening the apoptotic signaling pathway // Oncology Letters. 2021. Vol. 21. No. 6. 438
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Huang M., Yi C., Huang X., Yan J., Wei L., Tang W., Chen S., Huang Y. Recombinant protein TRAIL-Mu3 enhances the antitumor effects in pancreatic cancer cells by strengthening the apoptotic signaling pathway // Oncology Letters. 2021. Vol. 21. No. 6. 438
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TY - JOUR
DO - 10.3892/ol.2021.12699
UR - https://doi.org/10.3892/ol.2021.12699
TI - Recombinant protein TRAIL-Mu3 enhances the antitumor effects in pancreatic cancer cells by strengthening the apoptotic signaling pathway
T2 - Oncology Letters
AU - Huang, Min
AU - Yi, Cheng
AU - Huang, Xian-Zhou
AU - Yan, Juan
AU - Wei, Li-Jia
AU - Tang, Wei-Ju
AU - Chen, Shou-Chun
AU - Huang, Ying
PY - 2021
DA - 2021/04/01
PB - Spandidos Publications
IS - 6
VL - 21
PMID - 33868476
SN - 1792-1074
SN - 1792-1082
ER -
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@article{2021_Huang,
author = {Min Huang and Cheng Yi and Xian-Zhou Huang and Juan Yan and Li-Jia Wei and Wei-Ju Tang and Shou-Chun Chen and Ying Huang},
title = {Recombinant protein TRAIL-Mu3 enhances the antitumor effects in pancreatic cancer cells by strengthening the apoptotic signaling pathway},
journal = {Oncology Letters},
year = {2021},
volume = {21},
publisher = {Spandidos Publications},
month = {apr},
url = {https://doi.org/10.3892/ol.2021.12699},
number = {6},
pages = {438},
doi = {10.3892/ol.2021.12699}
}