Open Access

AIMS Biophysics, volume 9, issue 3, pages 282-293

Growth inhibition of cultured cancer cells by Ribes nigrum leaf extract

Mikayel Ginovyan ¹

Agnieszka Bartoszek ²

Izabela Koss-Mikołajczyk ²

Barbara Kusznierewicz ²

Pierre Andreoletti ³

Mustapha CHERKAOUI-MALKI ³

Naira Sahakyan ¹

Hide authors affiliations

Department of Biochemistry, Microbiology & Biotechnology; Research Institute of Biology Yerevan State University, 1 A. Manoogian Str., 0025 Yerevan, Armenia |

Department of Food Chemistry, Technology and Biotechnology, Faculty of Chemistry, Gdańsk University of Technology, Narutowicza 11/12, 80–233, Gdańsk, Poland |

Laboratoire Bio-PeroxIL EA7270, University of Bourgogne Franche-Comté, 21000 Dijon, France |

Publication type: Journal Article

Publication date: 2022-10-24

American Institute of Mathematical Sciences (AIMS)

Journal: AIMS Biophysics

scimago Q4

SJR: 0.220

CiteScore: 2.4

Impact factor: 1.1

ISSN: 23779098

DOI: 10.3934/biophy.2022024

Copy DOI

Biochemistry

Molecular Biology

Structural Biology

Biophysics

Abstract

<abstract> <p>The present article includes data on the possible selective cytotoxic effect of extract of <italic>Ribes nigrum</italic> L. growing at high Armenian landscape. For this purpose, different non-cancer (microglial BV-2 wild type (<italic>Wt</italic>), acyl-CoA oxidase 1 (ACOX1) deficient (<italic>Acox1<sup>−/−</sup></italic>) and cancer (human colon adenocarcinoma HT29 and human breast cancer MCF7) cell lines were applied. <italic>R. nigrum</italic> leaf ethanol extract showed a growth inhibition effect towards HT29 and MCF7 cells started from 6 h of treatment at the concentration of 0.5 mg/mL DW. The lowest concentration (0.125 mg/mL DW) of the investigated extract expressed cytotoxicity after 72 hours following cancer cell treatment. In contrast to the cancer cells, in the case of the tested non-cancer cells, cytotoxic effect was not observed at the applied concentrations. The extract sub-cytotoxic concentration, in this case, was reported to be the 1 mg/mL DW. Further investigations are needed to confirm the selective cytotoxicity and possible action mechanisms of the leaf extract of <italic>R. nigrum</italic>.</p> </abstract>

Found

	1
South African Journal of Botany	South African Journal of Botany, 1, 14.29% South African Journal of Botany 1 publication, 14.29%
Horticulturae	Horticulturae, 1, 14.29% Horticulturae 1 publication, 14.29%
Current Pharmacology Reports	Current Pharmacology Reports, 1, 14.29% Current Pharmacology Reports 1 publication, 14.29%
Plants	Plants, 1, 14.29% Plants 1 publication, 14.29%
BMC Complementary Medicine and Therapies	BMC Complementary Medicine and Therapies, 1, 14.29% BMC Complementary Medicine and Therapies 1 publication, 14.29%
	1

	1 2
MDPI	MDPI, 2, 28.57% MDPI 2 publications, 28.57%
Springer Nature	Springer Nature, 2, 28.57% Springer Nature 2 publications, 28.57%
Research Square Platform LLC	Research Square Platform LLC, 2, 28.57% Research Square Platform LLC 2 publications, 28.57%
Elsevier	Elsevier, 1, 14.29% Elsevier 1 publication, 14.29%
	1 2

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST | RIS | BibTex | MLA

Found error?

Publisher

American Institute of Mathematical Sciences (AIMS)

Journal

AIMS Biophysics

scimago Q4

SJR

0.220

CiteScore

2.4

Impact factor

1.1

ISSN

23779098 (Print, Electronic)

Growth inhibition of cultured cancer cells by Ribes nigrum leaf extract

Top-30

Journals

Publishers

Are you a researcher?