Synthesis, Crystal Structure and Antibacterial Activity of 4-Hydroxy-Benzaldehyde Benzoyl Hydrazone

A new aroylhydrazone compound of 4-hydroxybenzaldehyde benzoyl hydrazone was synthesized through the condensation of 4-hydroxybenzaldehyde and benzoyl hydrazine. The crystal structure was determined by single-crystal X-ray diffraction. It crystallizes in the orthorhombic system, space group Pbca with a=1.5514(3) nm, b=0.9318(16) nm, c=2.2921(4)nm, β=90.00o, Z=8, V=3.3137(10)nm3. Its crystal structure was determined and refined to a final R=0.0567 for 2725 independent reflections. The intermolecular hydrogen bonding interactions, C-O...N and O-H...O-C, connect the molecules into a layered network structure. The compound showed broad spectrum activity against S. aureus, E. Coli and P. Aeruginosa. The compound has the higher activity for Escherichia coli.