Journal of Immunology, volume 208, issue 5, pages 1139-1145
Boosting of the SARS-CoV-2–Specific Immune Response after Vaccination with Single-Dose Sputnik Light Vaccine
Dolzhikova Inna
2
,
Ефимов Г. А.
3
,
Logunov Denis Y.
2
,
Mityaeva Olga
4
,
Molodtsov Ivan A.
1
,
Naigovzina Nelli B.
5
,
Peshkova Iuliia
3
,
Shcheblyakov Dmitry V.
2
,
Volchkov Pavel
4, 6
,
Gintsburg Alexander L.
2
,
Vasilieva Elena
1, 5
1
*Clinical City Hospital named after I.V. Davydovsky, Moscow Department of Healthcare, Moscow, Russia;
|
4
Publication type: Journal Article
Publication date: 2022-03-01
Journal:
Journal of Immunology
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 4.4
ISSN: 00221767, 15506606
PubMed ID:
35101893
Immunology
Immunology and Allergy
Abstract
Despite measures taken world-wide, the coronavirus disease 2019 (COVID-19) pandemic continues. Because efficient antiviral drugs are not yet widely available, vaccination is the best option to control the infection rate. Although this option is obvious in the case of COVID-19–naive individuals, it is still unclear when individuals who have recovered from a previous SARS-CoV-2 infection should be vaccinated and whether the vaccination raises immune responses against the coronavirus and its novel variants. In this study, we collected peripheral blood from 84 healthy human donors of different COVID-19 status who were vaccinated with the Sputnik Light vaccine and measured the dynamics of the Ab and T cell responses, as well as the virus-neutralizing activity (VNA) in serum, against two SARS-CoV-2 variants, B.1.1.1 and B.1.617.2. We showed that vaccination of individuals previously exposed to the virus considerably boosts the existing immune response. In these individuals, receptor-binding domain (RBD)–specific IgG titers and VNA in serum were already elevated on the 7th day after vaccination, whereas COVID-19–naive individuals developed the Ab response and VNA mainly 21 d postvaccination. Additionally, we found a strong correlation between RBD-specific IgG titers and VNA in serum, and according to these data vaccination may be recommended when the RBD-specific IgG titers drop to 142.7 binding Ab units/ml or below. In summary, the results of the study demonstrate that vaccination is beneficial for both COVID-19–naive and recovered individuals, especially since it raises serum VNA against the B.1.617.2 variant, one of the five SARS-CoV-2 variants of concern.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Komissarov A. S. et al. Boosting of the SARS-CoV-2–Specific Immune Response after Vaccination with Single-Dose Sputnik Light Vaccine // Journal of Immunology. 2022. Vol. 208. No. 5. pp. 1139-1145.
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Komissarov A. S., Dolzhikova I., Ефимов Г. А., Logunov D. Y., Mityaeva O., Molodtsov I. A., Naigovzina N. B., Peshkova I., Shcheblyakov D. V., Volchkov P., Gintsburg A. L., Vasilieva E. Boosting of the SARS-CoV-2–Specific Immune Response after Vaccination with Single-Dose Sputnik Light Vaccine // Journal of Immunology. 2022. Vol. 208. No. 5. pp. 1139-1145.
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TY - JOUR
DO - 10.4049/jimmunol.2101052
UR - https://doi.org/10.4049%2Fjimmunol.2101052
TI - Boosting of the SARS-CoV-2–Specific Immune Response after Vaccination with Single-Dose Sputnik Light Vaccine
T2 - Journal of Immunology
AU - Komissarov, Alexey S.
AU - Dolzhikova, Inna
AU - Ефимов, Г. А.
AU - Logunov, Denis Y.
AU - Mityaeva, Olga
AU - Molodtsov, Ivan A.
AU - Naigovzina, Nelli B.
AU - Peshkova, Iuliia
AU - Shcheblyakov, Dmitry V.
AU - Volchkov, Pavel
AU - Gintsburg, Alexander L.
AU - Vasilieva, Elena
PY - 2022
DA - 2022/03/01 00:00:00
PB - The American Association of Immunologists
SP - 1139-1145
IS - 5
VL - 208
PMID - 35101893
SN - 0022-1767
SN - 1550-6606
ER -
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@article{2022_Komissarov,
author = {Alexey S. Komissarov and Inna Dolzhikova and Г. А. Ефимов and Denis Y. Logunov and Olga Mityaeva and Ivan A. Molodtsov and Nelli B. Naigovzina and Iuliia Peshkova and Dmitry V. Shcheblyakov and Pavel Volchkov and Alexander L. Gintsburg and Elena Vasilieva},
title = {Boosting of the SARS-CoV-2–Specific Immune Response after Vaccination with Single-Dose Sputnik Light Vaccine},
journal = {Journal of Immunology},
year = {2022},
volume = {208},
publisher = {The American Association of Immunologists},
month = {mar},
url = {https://doi.org/10.4049%2Fjimmunol.2101052},
number = {5},
pages = {1139--1145},
doi = {10.4049/jimmunol.2101052}
}
Cite this
MLA
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Komissarov, Alexey S., et al. “Boosting of the SARS-CoV-2–Specific Immune Response after Vaccination with Single-Dose Sputnik Light Vaccine.” Journal of Immunology, vol. 208, no. 5, Mar. 2022, pp. 1139-1145. https://doi.org/10.4049%2Fjimmunol.2101052.