Journal of Immunology, volume 133, issue 1, pages 180-189
The Fc receptor for IgG on human natural killer cells: phenotypic, functional, and comparative studies with monoclonal antibodies.
Publication type: Journal Article
Publication date: 1984-07-01
Journal:
Journal of Immunology
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 4.4
ISSN: 00221767, 15506606
Immunology
Immunology and Allergy
Abstract
We compare five monoclonal antibodies ( B73 .1, 3G8 , Leu- 11a , Leu- 11b , and VEP13 ) that react with natural killer (NK) cells and polymorphonuclear cells (PMN). We show that all of these antibodies are directed against and inhibit the functional properties of the receptor for the Fc portion of IgG (FcR). Modulation of the FcR on NK cells after reaction with immune complexes induces the disappearance of the antigen(s) recognized by each of the five antibodies. Conversely, the antibodies block binding of IgG-sensitized erythrocytes to the NK cells and PMN and inhibit their ability to mediate cytotoxicity against antibody-sensitized tumor target cells. By using two-color immunofluorescence techniques, we characterize directly the lymphocyte population recognized by these antibodies and show that it is a homogeneous subset that does not bear markers of either B or T cells, with the exception of the 33,000 dalton antigen characteristic of suppressor/cytotoxic T cells present in 20 to 50% of the cells, and the 45,000 dalton receptor for sheep erythrocytes present on 80 to 90% of the cells. The phenotype of the cells reacting with the monoclonal antibodies corresponds to that of NK cells. Cross-competition experiments indicate that these antibodies detect at least two distinct epitopes on FcR, one ( B73 .1) preferentially expressed on NK cells and one or more ( 3G8 /Leu- 11a /Leu- 11b / VEP13 ) preferentially expressed on PMN. The lack of reactivity of these antibodies with B cells suggests that human B cells bear a different FcR from that on NK cells and PMN.
Top-30
Citations by journals
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Journal of Immunology
3 publications, 10.34%
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Advances in Immunology
2 publications, 6.9%
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Science
1 publication, 3.45%
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Blood
1 publication, 3.45%
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Annual Review of Immunology
1 publication, 3.45%
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Scientific Reports
1 publication, 3.45%
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Acute Leukemias
1 publication, 3.45%
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Medical Science Symposia Series
1 publication, 3.45%
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Ciba Foundation Symposium - Aetiology of Diabetes Mellitus and its Complications (Colloquia on Endocrinology, Vol. 15)
1 publication, 3.45%
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Advances in Cell Aging and Gerontology
1 publication, 3.45%
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Methods in Enzymology
1 publication, 3.45%
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Advances in Cellular and Molecular Biology of Membranes and Organelles
1 publication, 3.45%
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Mucosal Immunology
1 publication, 3.45%
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Glycobiology
1 publication, 3.45%
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Russian Chemical Reviews
1 publication, 3.45%
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3
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Citations by publishers
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9
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Elsevier
9 publications, 31.03%
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The American Association of Immunologists
3 publications, 10.34%
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Springer Nature
3 publications, 10.34%
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Wiley
2 publications, 6.9%
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American Association for the Advancement of Science (AAAS)
1 publication, 3.45%
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American Society of Hematology
1 publication, 3.45%
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Annual Reviews
1 publication, 3.45%
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Oxford University Press
1 publication, 3.45%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 3.45%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Perussia B. et al. The Fc receptor for IgG on human natural killer cells: phenotypic, functional, and comparative studies with monoclonal antibodies. // Journal of Immunology. 1984. Vol. 133. No. 1. pp. 180-189.
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Perussia B., Trinchieri G., JACKSON A., WARNER N., FAUST J., Rumpold H., Kraft D., LANIER L. L. The Fc receptor for IgG on human natural killer cells: phenotypic, functional, and comparative studies with monoclonal antibodies. // Journal of Immunology. 1984. Vol. 133. No. 1. pp. 180-189.
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TY - JOUR
DO - 10.4049/jimmunol.133.1.180
UR - https://doi.org/10.4049/jimmunol.133.1.180
TI - The Fc receptor for IgG on human natural killer cells: phenotypic, functional, and comparative studies with monoclonal antibodies.
T2 - Journal of Immunology
AU - Perussia, B.
AU - Trinchieri, G.
AU - JACKSON, A
AU - WARNER, N.L.
AU - FAUST, J.
AU - Rumpold, H.
AU - Kraft, D.
AU - LANIER, LEWIS L.
PY - 1984
DA - 1984/07/01 00:00:00
PB - The American Association of Immunologists
SP - 180-189
IS - 1
VL - 133
SN - 0022-1767
SN - 1550-6606
ER -
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@article{1984_Perussia,
author = {B. Perussia and G. Trinchieri and A JACKSON and N.L. WARNER and J. FAUST and H. Rumpold and D. Kraft and LEWIS L. LANIER},
title = {The Fc receptor for IgG on human natural killer cells: phenotypic, functional, and comparative studies with monoclonal antibodies.},
journal = {Journal of Immunology},
year = {1984},
volume = {133},
publisher = {The American Association of Immunologists},
month = {jul},
url = {https://doi.org/10.4049/jimmunol.133.1.180},
number = {1},
pages = {180--189},
doi = {10.4049/jimmunol.133.1.180}
}
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Perussia, B., et al. “The Fc receptor for IgG on human natural killer cells: phenotypic, functional, and comparative studies with monoclonal antibodies..” Journal of Immunology, vol. 133, no. 1, Jul. 1984, pp. 180-189. https://doi.org/10.4049/jimmunol.133.1.180.