Ovid Technologies (Wolters Kluwer Health)
Egyptian Journal of Dermatology and Venerology
,  volume 45 ,  issue 1 ,  pages 61-67

Estimation of melanocytic count in different donor areas in non-segmental vitiligo before and after narrow band ultraviolet B phototherapy

Publication type: Journal Article
Publication date: 2025-01-01
Ovid Technologies (Wolters Kluwer Health)
wos Q4
SJR: —
CiteScore: —
Impact factor: 0.1
ISSN: 11106530, 23147407
Abstract
Background

The gluteal region and thigh are common donor sites used during surgical treatment of stable nonsegmental vitiligo (NSV). The outcome of transplantation could be improved if the donor site has higher melanocyte density.

Aim

To compare the count of melanocytes in the gluteal region and thigh, and evaluate the impact of narrow band ultraviolet B (NB-UVB) phototherapy on the quantity of melanocytes in both areas.

Methods

In this study, 20 stable NSV patients and five controls were included. Before and after 18 sessions of NB-UVB, two 3 mm punch biopsies were obtained from the normal skin of the thigh and gluteal region. Melan A was used for immunohistochemically labeling, and a count of melanocytes was performed on each sample.

Results

Before NB-UVB therapy, there was no significant difference in the number of melanocytic cells in the gluteal region and thigh in NSV patients (P=0.777) or between cases and controls. In NSV cases, the melanocytic count increased significantly in the thigh and gluteal region (P=0.002 for both), with no difference observed between the two sites (P=0.430). In the gluteal region, there was a significant positive correlation between the total cumulative joules (P=0.025, r=0.511) and the percentage change of melanocytic count and skin phototype (P=0.001, r=0.677).

Conclusion

In NSV patients, the melanocytic count in the normal skin of the thigh and gluteal region is similar. Following NB-UVB, this count significantly increased in both sites similarly. Both sites are equally appopriate for harvesting donor tissue for surgery in NSV cases preferably after NB-UVB phototherapy.

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Hussien M. F. et al. Estimation of melanocytic count in different donor areas in non-segmental vitiligo before and after narrow band ultraviolet B phototherapy // Egyptian Journal of Dermatology and Venerology. 2025. Vol. 45. No. 1. pp. 61-67.
GOST all authors (up to 50) Copy
Hussien M. F., Bassiouny D. A., El Maadawi Z. M., Soliman A. M., Al-Boani A. M., El Zawahry Y. B. Estimation of melanocytic count in different donor areas in non-segmental vitiligo before and after narrow band ultraviolet B phototherapy // Egyptian Journal of Dermatology and Venerology. 2025. Vol. 45. No. 1. pp. 61-67.
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RIS Copy
TY - JOUR
DO - 10.4103/ejdv.ejdv_20_24
UR - https://journals.lww.com/10.4103/ejdv.ejdv_20_24
TI - Estimation of melanocytic count in different donor areas in non-segmental vitiligo before and after narrow band ultraviolet B phototherapy
T2 - Egyptian Journal of Dermatology and Venerology
AU - Hussien, Marwa F
AU - Bassiouny, Dalia A
AU - El Maadawi, Zeinab M.
AU - Soliman, Ahmed M.
AU - Al-Boani, Asmaa M.
AU - El Zawahry, Yasmin B.
PY - 2025
DA - 2025/01/01
PB - Ovid Technologies (Wolters Kluwer Health)
SP - 61-67
IS - 1
VL - 45
SN - 1110-6530
SN - 2314-7407
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2025_Hussien,
author = {Marwa F Hussien and Dalia A Bassiouny and Zeinab M. El Maadawi and Ahmed M. Soliman and Asmaa M. Al-Boani and Yasmin B. El Zawahry},
title = {Estimation of melanocytic count in different donor areas in non-segmental vitiligo before and after narrow band ultraviolet B phototherapy},
journal = {Egyptian Journal of Dermatology and Venerology},
year = {2025},
volume = {45},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
month = {jan},
url = {https://journals.lww.com/10.4103/ejdv.ejdv_20_24},
number = {1},
pages = {61--67},
doi = {10.4103/ejdv.ejdv_20_24}
}
MLA
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MLA Copy
Hussien, Marwa F., et al. “Estimation of melanocytic count in different donor areas in non-segmental vitiligo before and after narrow band ultraviolet B phototherapy.” Egyptian Journal of Dermatology and Venerology, vol. 45, no. 1, Jan. 2025, pp. 61-67. https://journals.lww.com/10.4103/ejdv.ejdv_20_24.