Comparative study of serum albumin, serum cholestrol and liver enzymes in individuals having senile cataract versus normal individuals
Background:
One of the often-seen consequences of the aging process is the development of senile cataracts, a disease that affects one of our most precious gifts, that of sight. Many factors such as aging, changes in blood electrolyte levels, and possibly family history are involved in senile cataract formation. Changes in serum electrolyte levels can induce changes in aqueous electrolyte levels and affect lens metabolism and probably cataract formation.
Aims:
We aimed to measure the level of serum albumin, serum cholesterol, and liver enzymes in senile cataractous lens and normal crystalline lens. To analyze the correlation of serum albumin, serum cholesterol, and liver enzymes with cataractogenesis.
Materials and Methods:
This prospective case–control study was performed on 160 patients who presented to the Ophthalmology Outpatient Department of Jawaharlal Nehru Medical College and Hospital in collaboration with the Department of Biochemistry, Aligarh Muslim University, Aligarh, Uttar Pradesh, India, over 2 years (from December 2016 to December 2018), study group comprised of 100 patients and the control group comprised of 60 patients. Statistical Package for Social Sciences software was used for data analysis.
Results:
The two groups were comparable concerning age. There were no significant statistical differences between the groups in terms of age. However, there was a statistically significant difference in intraocular pressure (IOP) and visual acuity (
Conclusion:
This study demonstrates that deranged liver enzymes have some role in cataract formation, and are associated with decreased serum albumin levels and it increases the chances of cortical cataract followed by nuclear cataract. Increased serum cholesterol levels are also associated with increased chances of mixed cataracts followed by cortical cataracts.
