Effect of HDF on obestatin level as a marker of malnutrition in hemodialysis patients

Waleed A. Abd Elmohsen 1
, 
Asmaa M. Youssef 2
, 
Mohamed S. Hassan 1
1
 
2
 
Department of Nephrology, Al-Mounira General Hospital, Cairo, Egypt | 
Publication type: Journal Article
Publication date: 2025-01-08
Ovid Technologies (Wolters Kluwer Health)
SJR: —
CiteScore: —
Impact factor: —
ISSN: 11109165, 23569387
Abstract
Background

Obestatin is a proposed anorexigenic gut peptide, known as appetite regulatory hormone. We postulated a potential correlation between obestatin level and malnutrition in hemodialysis (HD) patients. Measurement of obestatin concentration in HD patients would help to evaluate the possible participation of this hormone in protein energy wasting in maintenance HD patients. The objective of this study is to assay the effect of hemodiafiltration (HDF) on serum obestatin level in prevalent HD patients.

Patients and methods

This cross-sectional study included 40 prevalent HD patients: (20 patients maintained on high-flux HD) and (20 patients maintained on online HDF), 20 healthy individuals served as controls. Full history in detail was taken and a full clinical examination was done, with malnutrition-inflammation score calculation. Routine laboratory analysis was performed also, with evaluation of serum obestatin level pre and post session by enzyme linked immunosorbent assay.

Results

BMI was statistically significantly lower in HD and HDF groups compared with the control group (P= 0.002). Obestatin level was significantly higher predialysis in HD and HDF groups in comparison to the control group (P value < 0.000), with a higher obestatin reduction ratio post sessions in HDF group than HD group. (P value < 0.001). Obestatin concentration negatively correlated with weight, height, BMI, low-density lipoprotein, and S iron (P value < 0.05), while positively correlated with creatinine, urea, uric acid, and C-reactive protein (P value < 0.05). Regression analysis showed that serum obestatin was independently affected by serum low-density lipoprotein level.

Conclusion

The current observational data suggests that obestatin hormone was elevated in prevalent HD patients (high-flux HD group and online HDF group) than control group, this hormone might be a marker of inflammation and dyslipidemia. Obestatin removal was better by online HDF than high flux HD.

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Abd Elmohsen W. A., Youssef A. M., Hassan M. S. Effect of HDF on obestatin level as a marker of malnutrition in hemodialysis patients // Journal of The Egyptian Society of Nephrology and Transplantation. 2025. Vol. 25. No. 1. pp. 8-19.
GOST all authors (up to 50) Copy
Abd Elmohsen W. A., Youssef A. M., Hassan M. S. Effect of HDF on obestatin level as a marker of malnutrition in hemodialysis patients // Journal of The Egyptian Society of Nephrology and Transplantation. 2025. Vol. 25. No. 1. pp. 8-19.
RIS |
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RIS Copy
TY - JOUR
DO - 10.4103/jesnt.jesnt_10_24
UR - https://journals.lww.com/10.4103/jesnt.jesnt_10_24
TI - Effect of HDF on obestatin level as a marker of malnutrition in hemodialysis patients
T2 - Journal of The Egyptian Society of Nephrology and Transplantation
AU - Abd Elmohsen, Waleed A.
AU - Youssef, Asmaa M.
AU - Hassan, Mohamed S.
PY - 2025
DA - 2025/01/08
PB - Ovid Technologies (Wolters Kluwer Health)
SP - 8-19
IS - 1
VL - 25
SN - 1110-9165
SN - 2356-9387
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2025_Abd Elmohsen,
author = {Waleed A. Abd Elmohsen and Asmaa M. Youssef and Mohamed S. Hassan},
title = {Effect of HDF on obestatin level as a marker of malnutrition in hemodialysis patients},
journal = {Journal of The Egyptian Society of Nephrology and Transplantation},
year = {2025},
volume = {25},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
month = {jan},
url = {https://journals.lww.com/10.4103/jesnt.jesnt_10_24},
number = {1},
pages = {8--19},
doi = {10.4103/jesnt.jesnt_10_24}
}
MLA
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Abd Elmohsen, Waleed A., et al. “Effect of HDF on obestatin level as a marker of malnutrition in hemodialysis patients.” Journal of The Egyptian Society of Nephrology and Transplantation, vol. 25, no. 1, Jan. 2025, pp. 8-19. https://journals.lww.com/10.4103/jesnt.jesnt_10_24.