Antimicrobial Efficacy of Irrigation with 4.8% Bromelain Extract against Porphyromonas gingivalis in the Periodontal Pockets: A Randomized Controlled Trial
Background and Objective:
Bromelain, extracted from pineapple, is one of the best-known plant proteases. It has been shown to inhibit the growth of
Methodology:
A randomized controlled clinical trial with a parallel-group design was conducted involving 24 adults with a periodontal pocket of 5 mm or more depth, who were randomly allocated to the two interventional groups. In each individual, the pocket of the selected tooth was irrigated with 3 ml of interventional irrigants (0.2% chlorhexidine and 4.8% bromelain extract) once, 24 h after supragingival scaling. The baseline subgingival sample was collected using paper points before irrigation, and the second sample was collected on the 7th day after irrigation. Real-time polymerase chain reaction quantitative microbial analysis was done. The Mann–Whitney
Results:
There was a significant postirrigation reduction in the level of
Conclusion:
Periodontal pocket irrigation with 4.8% bromelain resulted in a clinically significant reduction of
