Open Access
In Vitro Comparison of the Efficacy of Different Soft Tissue Grafting Materials in Promoting Fibroblast Proliferation
Senthilnathan Rajendran
1
,
Neelam Das
2
,
Atika Ismail
3
,
Rupali Ravindra Borade
4
,
Anitha Subbappa
5
,
Lakshmi S. Anand
6
1
Professor, Department of Oral and Maxillofacial Surgery, Sree Balaji Dental College and Hospital, Chennai, Tamil Nadu, India
|
2
Associate Professor, Department of Periodontology, Sri Sai College of Dental Surgery, Vikarabad, Telangana, India
|
3
Consultant Periodontist, Department of Periodontology, Kothiwal Dental College and Research Centre, Moradabad, Uttar Pradesh, India
|
4
Senior Lecturer, Department of Periodontology, SMBT Dental College and Hospital, Sangamner, Maharashtra, India
|
6
Senior Resident, Department of Oral Pathology and Microbiology, Govt Dental College, Thrissur, Kerala, India
|
Publication type: Journal Article
Publication date: 2025-07-01
scimago Q2
wos Q4
SJR: 0.323
CiteScore: —
Impact factor: 0.9
ISSN: 09764879, 09757406
Abstract
ABSTRACT
Objective:
This study evaluated the ability of Fibro-Gide® and Mucoderm® collagen matrices to stimulate fibroblast proliferation.
Materials and Methods:
The study tested two collagen matrices, Mucoderm® and Fibro-Gide®, on human gingival fibroblasts. Surface roughness, cell viability, and collagen quantities were measured using profilometers and ELISA.
Results:
Fibro-Gide® outperformed Mucoderm® in terms of surface roughness (2.75 μm) and cell survival, while ELISA findings showed a greater collagen type and a higher optical density (0.920 OD).
Conclusion:
Fibro-Gide® showed better fibroblast proliferation and extracellular matrix production, indicating promise for tissue regeneration and remodeling in periodontal and peri-implant applications, while Mucoderm® remains viable.
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Rajendran S. et al. In Vitro Comparison of the Efficacy of Different Soft Tissue Grafting Materials in Promoting Fibroblast Proliferation // Journal of Pharmacy and Bioallied Sciences. 2025. Vol. 17. No. Suppl 3. p. S2665-S2667.
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Rajendran S., Das N., Ismail A., Borade R. R., Subbappa A., Anand L. S. In Vitro Comparison of the Efficacy of Different Soft Tissue Grafting Materials in Promoting Fibroblast Proliferation // Journal of Pharmacy and Bioallied Sciences. 2025. Vol. 17. No. Suppl 3. p. S2665-S2667.
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TY - JOUR
DO - 10.4103/jpbs.jpbs_740_25
UR - https://journals.lww.com/10.4103/jpbs.jpbs_740_25
TI - In Vitro Comparison of the Efficacy of Different Soft Tissue Grafting Materials in Promoting Fibroblast Proliferation
T2 - Journal of Pharmacy and Bioallied Sciences
AU - Rajendran, Senthilnathan
AU - Das, Neelam
AU - Ismail, Atika
AU - Borade, Rupali Ravindra
AU - Subbappa, Anitha
AU - Anand, Lakshmi S.
PY - 2025
DA - 2025/07/01
PB - Ovid Technologies (Wolters Kluwer Health)
SP - S2665-S2667
IS - Suppl 3
VL - 17
SN - 0976-4879
SN - 0975-7406
ER -
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@article{2025_Rajendran,
author = {Senthilnathan Rajendran and Neelam Das and Atika Ismail and Rupali Ravindra Borade and Anitha Subbappa and Lakshmi S. Anand},
title = {In Vitro Comparison of the Efficacy of Different Soft Tissue Grafting Materials in Promoting Fibroblast Proliferation},
journal = {Journal of Pharmacy and Bioallied Sciences},
year = {2025},
volume = {17},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
month = {jul},
url = {https://journals.lww.com/10.4103/jpbs.jpbs_740_25},
number = {Suppl 3},
pages = {S2665--S2667},
doi = {10.4103/jpbs.jpbs_740_25}
}
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MLA
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Rajendran, Senthilnathan, et al. “In Vitro Comparison of the Efficacy of Different Soft Tissue Grafting Materials in Promoting Fibroblast Proliferation.” Journal of Pharmacy and Bioallied Sciences, vol. 17, no. Suppl 3, Jul. 2025, pp. S2665-S2667. https://journals.lww.com/10.4103/jpbs.jpbs_740_25.