GABAA receptor family: overview on structural characterization
María Julia Amundarain
1
,
Rui Pedro Ribeiro
2
,
Marcelo Daniel Costabel
1
,
Alejandro Giorgetti
2, 3
Publication type: Journal Article
Publication date: 2019-02-25
scimago Q3
wos Q2
SJR: 0.501
CiteScore: 4.8
Impact factor: 3.4
ISSN: 17568919, 17568927
PubMed ID:
30801199
Drug Discovery
Pharmacology
Molecular Medicine
Abstract
The pentameric γ-aminobutyric acid type A receptors are ion channels activated by ligands, which intervene in the rapid inhibitory transmission in the mammalian CNS. Due to their rich pharmacology and therapeutic potential, it is essential to understand their structure and function thoroughly. This deep characterization was hampered by the lack of experimental structural information for many years. Thus, computational techniques have been extensively combined with experimental data, in order to undertake the study of γ-aminobutyric acid type A receptors and their interaction with drugs. Here, we review the exciting journey made to assess the structures of these receptors and outline major outcomes. Finally, we discuss the brand new structure of the α1β2γ2 subtype and the amazing advances it brings to the field.
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Metrics
14
Total citations:
14
Citations from 2025:
3
(21.43%)
Cite this
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RIS |
BibTex |
MLA
Cite this
GOST
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Amundarain M. J. et al. GABAA receptor family: overview on structural characterization // Future Medicinal Chemistry. 2019. Vol. 11. No. 3. pp. 229-245.
GOST all authors (up to 50)
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Amundarain M. J., Ribeiro R. P., Costabel M. D., Giorgetti A. GABAA receptor family: overview on structural characterization // Future Medicinal Chemistry. 2019. Vol. 11. No. 3. pp. 229-245.
Cite this
RIS
Copy
TY - JOUR
DO - 10.4155/fmc-2018-0336
UR - https://doi.org/10.4155/fmc-2018-0336
TI - GABAA receptor family: overview on structural characterization
T2 - Future Medicinal Chemistry
AU - Amundarain, María Julia
AU - Ribeiro, Rui Pedro
AU - Costabel, Marcelo Daniel
AU - Giorgetti, Alejandro
PY - 2019
DA - 2019/02/25
PB - Taylor & Francis
SP - 229-245
IS - 3
VL - 11
PMID - 30801199
SN - 1756-8919
SN - 1756-8927
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Amundarain,
author = {María Julia Amundarain and Rui Pedro Ribeiro and Marcelo Daniel Costabel and Alejandro Giorgetti},
title = {GABAA receptor family: overview on structural characterization},
journal = {Future Medicinal Chemistry},
year = {2019},
volume = {11},
publisher = {Taylor & Francis},
month = {feb},
url = {https://doi.org/10.4155/fmc-2018-0336},
number = {3},
pages = {229--245},
doi = {10.4155/fmc-2018-0336}
}
Cite this
MLA
Copy
Amundarain, María Julia, et al. “GABAA receptor family: overview on structural characterization.” Future Medicinal Chemistry, vol. 11, no. 3, Feb. 2019, pp. 229-245. https://doi.org/10.4155/fmc-2018-0336.