Phosphonate prodrugs: an overview and recent advances
Publication type: Journal Article
Publication date: 2019-08-30
scimago Q3
wos Q2
SJR: 0.501
CiteScore: 4.8
Impact factor: 3.4
ISSN: 17568919, 17568927
PubMed ID:
31469328
Drug Discovery
Pharmacology
Molecular Medicine
Abstract
Phosphonates, often used as isosteric replacements for phosphates, can provide important interactions with an enzyme. Due to their high charge at physiological pH, however, permeation into cells can be a challenge. Protecting phosphonates as prodrugs has shown promise in drug delivery. Thus, a variety of structures and cleavage/activation mechanisms exist, enabling release of the active compound. This review describes the structural diversity of these pro-moieties, relevant cleavage mechanisms and recent advances in the design of phosphonate prodrugs.
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Metrics
92
Total citations:
92
Citations from 2025:
17
(18.48%)
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GOST
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Heidel K. M., Dowd C. S. Phosphonate prodrugs: an overview and recent advances // Future Medicinal Chemistry. 2019. Vol. 11. No. 13. pp. 1625-1643.
GOST all authors (up to 50)
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Heidel K. M., Dowd C. S. Phosphonate prodrugs: an overview and recent advances // Future Medicinal Chemistry. 2019. Vol. 11. No. 13. pp. 1625-1643.
Cite this
RIS
Copy
TY - JOUR
DO - 10.4155/fmc-2018-0591
UR - https://doi.org/10.4155/fmc-2018-0591
TI - Phosphonate prodrugs: an overview and recent advances
T2 - Future Medicinal Chemistry
AU - Heidel, Kenneth M
AU - Dowd, Cynthia S
PY - 2019
DA - 2019/08/30
PB - Taylor & Francis
SP - 1625-1643
IS - 13
VL - 11
PMID - 31469328
SN - 1756-8919
SN - 1756-8927
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Heidel,
author = {Kenneth M Heidel and Cynthia S Dowd},
title = {Phosphonate prodrugs: an overview and recent advances},
journal = {Future Medicinal Chemistry},
year = {2019},
volume = {11},
publisher = {Taylor & Francis},
month = {aug},
url = {https://doi.org/10.4155/fmc-2018-0591},
number = {13},
pages = {1625--1643},
doi = {10.4155/fmc-2018-0591}
}
Cite this
MLA
Copy
Heidel, Kenneth M., and Cynthia S Dowd. “Phosphonate prodrugs: an overview and recent advances.” Future Medicinal Chemistry, vol. 11, no. 13, Aug. 2019, pp. 1625-1643. https://doi.org/10.4155/fmc-2018-0591.