pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast
Christopher Murakami
1
,
Joe Delaney
2, 3, 4, 5
,
Annie Chou
1
,
Daniel Carr
1
,
Jennifer Schleit
1
,
George L Sutphin
2, 3, 4, 5
,
Elroy H An
1
,
Anthony S Castanza
1
,
Marissa Fletcher
1
,
Sarani Goswami
1
,
Sean Higgins
1
,
Mollie Holmberg
1
,
Jessica Hui
1
,
Monika Jelic
1
,
Ki Soo Jeong
1
,
Jin R Kim
1
,
Shannon Klum
1
,
Eric Liao
1
,
Michael S Lin
1
,
Winston Lo
1
,
Hillary A. Miller
1
,
Richard Möller
1
,
Zhao J Peng
1
,
Tom Pollard
1
,
Prarthana Pradeep
1
,
Dillon Pruett
1
,
Dilreet Rai
1
,
Vanessa Ros
1
,
Alex Schuster
1
,
Minnie Singh
1
,
Benjamin L. Spector
1
,
Helen Vander Wende
1
,
Adrienne M. Wang
1
,
Brian M Wasko
1
,
Brady Olsen
1
,
Matt Kaeberlein
2, 3, 4, 6, 7, 8
2
Department of Pathology
4
Seattle, WA USA
|
5
Molecular and Cellular Biology Program
6
Institute of Aging Research
8
Dongguan, China
|
Publication type: Journal Article
Publication date: 2012-08-15
scimago Q1
wos Q3
SJR: 0.937
CiteScore: 7.9
Impact factor: 3.4
ISSN: 15384101, 15514005
DOI:
10.4161/cc.21465
PubMed ID:
22871733
Molecular Biology
Cell Biology
Developmental Biology
Abstract
Chronological and replicative aging have been studied in yeast as alternative paradigms for post-mitotic and mitotic aging, respectively. It has been known for more than a decade that cells of the S288C background aged chronologically in rich medium have reduced replicative lifespan relative to chronologically young cells. Here we report replication of this observation in the diploid BY4743 strain background. We further show that the reduction in replicative lifespan from chronological aging is accelerated when cells are chronologically aged under standard conditions in synthetic complete medium rather than rich medium. The loss of replicative potential with chronological age is attenuated by buffering the pH of the chronological aging medium to 6.0, an intervention that we have previously shown can extend chronological lifespan. These data demonstrate that extracellular acidification of the culture medium can cause intracellular damage in the chronologically aging population that is asymmetrically segregated by the mother cell to limit subsequent replicative lifespan.
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Total citations:
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Citations from 2024:
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GOST
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Murakami C. et al. pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast // Cell Cycle. 2012. Vol. 11. No. 16. pp. 3087-3096.
GOST all authors (up to 50)
Copy
Murakami C., Delaney J., Chou A., Carr D., Schleit J., Sutphin G. L., An E. H., Castanza A. S., Fletcher M., Goswami S., Higgins S., Holmberg M., Hui J., Jelic M., Jeong K. S., Kim J. R., Klum S., Liao E., Lin M. S., Lo W., Miller H. A., Möller R., Peng Z. J., Pollard T., Pradeep P., Pruett D., Rai D., Ros V., Schuster A., Singh M., Spector B. L., Vander Wende H., Wang A. M., Wasko B. M., Olsen B., Kaeberlein M. pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast // Cell Cycle. 2012. Vol. 11. No. 16. pp. 3087-3096.
Cite this
RIS
Copy
TY - JOUR
DO - 10.4161/cc.21465
UR - https://doi.org/10.4161/cc.21465
TI - pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast
T2 - Cell Cycle
AU - Murakami, Christopher
AU - Delaney, Joe
AU - Chou, Annie
AU - Carr, Daniel
AU - Schleit, Jennifer
AU - Sutphin, George L
AU - An, Elroy H
AU - Castanza, Anthony S
AU - Fletcher, Marissa
AU - Goswami, Sarani
AU - Higgins, Sean
AU - Holmberg, Mollie
AU - Hui, Jessica
AU - Jelic, Monika
AU - Jeong, Ki Soo
AU - Kim, Jin R
AU - Klum, Shannon
AU - Liao, Eric
AU - Lin, Michael S
AU - Lo, Winston
AU - Miller, Hillary A.
AU - Möller, Richard
AU - Peng, Zhao J
AU - Pollard, Tom
AU - Pradeep, Prarthana
AU - Pruett, Dillon
AU - Rai, Dilreet
AU - Ros, Vanessa
AU - Schuster, Alex
AU - Singh, Minnie
AU - Spector, Benjamin L.
AU - Vander Wende, Helen
AU - Wang, Adrienne M.
AU - Wasko, Brian M
AU - Olsen, Brady
AU - Kaeberlein, Matt
PY - 2012
DA - 2012/08/15
PB - Taylor & Francis
SP - 3087-3096
IS - 16
VL - 11
PMID - 22871733
SN - 1538-4101
SN - 1551-4005
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2012_Murakami,
author = {Christopher Murakami and Joe Delaney and Annie Chou and Daniel Carr and Jennifer Schleit and George L Sutphin and Elroy H An and Anthony S Castanza and Marissa Fletcher and Sarani Goswami and Sean Higgins and Mollie Holmberg and Jessica Hui and Monika Jelic and Ki Soo Jeong and Jin R Kim and Shannon Klum and Eric Liao and Michael S Lin and Winston Lo and Hillary A. Miller and Richard Möller and Zhao J Peng and Tom Pollard and Prarthana Pradeep and Dillon Pruett and Dilreet Rai and Vanessa Ros and Alex Schuster and Minnie Singh and Benjamin L. Spector and Helen Vander Wende and Adrienne M. Wang and Brian M Wasko and Brady Olsen and Matt Kaeberlein},
title = {pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast},
journal = {Cell Cycle},
year = {2012},
volume = {11},
publisher = {Taylor & Francis},
month = {aug},
url = {https://doi.org/10.4161/cc.21465},
number = {16},
pages = {3087--3096},
doi = {10.4161/cc.21465}
}
Cite this
MLA
Copy
Murakami, Christopher, et al. “pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast.” Cell Cycle, vol. 11, no. 16, Aug. 2012, pp. 3087-3096. https://doi.org/10.4161/cc.21465.