Hyaluronic acid: A key molecule in skin aging
1
Department of Pharmacology
2
School of Medicine
4
Thessaloniki, Greece
|
5
Pulmonary Cell Research-Pneumology
7
Basel, Switzerland
|
Publication type: Journal Article
Publication date: 2012-07-01
SJR: —
CiteScore: —
Impact factor: —
ISSN: 19381972, 19381980
PubMed ID:
23467280
Endocrinology, Diabetes and Metabolism
Dermatology
Abstract
Skin aging is a multifactorial process consisting of two distinct and independent mechanisms: intrinsic and extrinsic aging. Youthful skin retains its turgor, resilience and pliability, among others, due to its high content of water. Daily external injury, in addition to the normal process of aging, causes loss of moisture. The key molecule involved in skin moisture is hyaluronic acid (HA) that has unique capacity in retaining water. There are multiple sites for the control of HA synthesis, deposition, cell and protein association and degradation, reflecting the complexity of HA metabolism. The enzymes that synthesize or catabolize HA and HA receptors responsible for many of the functions of HA are all multigene families with distinct patterns of tissue expression. Understanding the metabolism of HA in the different layers of the skin and the interactions of HA with other skin components will facilitate the ability to modulate skin moisture in a rational manner.
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806
Total citations:
806
Citations from 2025:
135
(16.75%)
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GOST
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Papakonstantinou E. et al. Hyaluronic acid: A key molecule in skin aging // Dermato-Endocrinology. 2012. Vol. 4. No. 3. pp. 253-258.
GOST all authors (up to 50)
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Papakonstantinou E., Roth M., Karakiulakis G. Hyaluronic acid: A key molecule in skin aging // Dermato-Endocrinology. 2012. Vol. 4. No. 3. pp. 253-258.
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RIS
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TY - JOUR
DO - 10.4161/derm.21923
UR - https://doi.org/10.4161/derm.21923
TI - Hyaluronic acid: A key molecule in skin aging
T2 - Dermato-Endocrinology
AU - Papakonstantinou, E
AU - Roth, M
AU - Karakiulakis, G.
PY - 2012
DA - 2012/07/01
PB - Taylor & Francis
SP - 253-258
IS - 3
VL - 4
PMID - 23467280
SN - 1938-1972
SN - 1938-1980
ER -
Cite this
BibTex (up to 50 authors)
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@article{2012_Papakonstantinou,
author = {E Papakonstantinou and M Roth and G. Karakiulakis},
title = {Hyaluronic acid: A key molecule in skin aging},
journal = {Dermato-Endocrinology},
year = {2012},
volume = {4},
publisher = {Taylor & Francis},
month = {jul},
url = {https://doi.org/10.4161/derm.21923},
number = {3},
pages = {253--258},
doi = {10.4161/derm.21923}
}
Cite this
MLA
Copy
Papakonstantinou, E., et al. “Hyaluronic acid: A key molecule in skin aging.” Dermato-Endocrinology, vol. 4, no. 3, Jul. 2012, pp. 253-258. https://doi.org/10.4161/derm.21923.