Open Access
Cell Cycle, volume 4, issue 11, pages 1467-1470
Fine-Tuning the Chromosome Ends: The Last Base of Human Telomeres
Publication type: Journal Article
Publication date: 2005-08-22
Molecular Biology
Cell Biology
Developmental Biology
Abstract
Telomeres protect chromosome from degradation and loss of vital sequence, block end-end fusion, and allow the cell to distinguish between broken ends and chromosome ends. Mammalian telomeres end in single-stranded (TTAGGG)-rich 3’-overhangs that are tucked back into the preceding double stranded region to form a T-loop. The end structure of mammalian telomeres has just started to be elucidated and through this extra views we highlight one aspect of that structure. We have recently identified the terminal nucleotides of both the C-rich and G-rich telomere strands in human cells and showed that ~ 80 % of the C-rich strands terminate precisely in ATC-5’, while the last base of the G-strand is less precise. This finding has important implications for the processing events that act on the telomere ends post-replication. While the mechanism behind this phenotype is yet to be unraveled, we discuss potential models that could explain the last base specificity.
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2 publications, 15.38%
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Citations by publishers
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Springer Nature
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2 publications, 15.38%
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1 publication, 7.69%
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1 publication, 7.69%
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American Society for Biochemistry and Molecular Biology
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1 publication, 7.69%
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Wiley
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Wiley
1 publication, 7.69%
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1
2
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Sfeir A. J., Shay J. W., Wright W. E. Fine-Tuning the Chromosome Ends: The Last Base of Human Telomeres // Cell Cycle. 2005. Vol. 4. No. 11. pp. 1467-1470.
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Sfeir A. J., Shay J. W., Wright W. E. Fine-Tuning the Chromosome Ends: The Last Base of Human Telomeres // Cell Cycle. 2005. Vol. 4. No. 11. pp. 1467-1470.
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TY - JOUR
DO - 10.4161/cc.4.11.2161
UR - https://doi.org/10.4161%2Fcc.4.11.2161
TI - Fine-Tuning the Chromosome Ends: The Last Base of Human Telomeres
T2 - Cell Cycle
AU - Sfeir, Agnel J.
AU - Shay, Jerry W.
AU - Wright, Woodring E.
PY - 2005
DA - 2005/08/22 00:00:00
PB - Taylor & Francis
SP - 1467-1470
IS - 11
VL - 4
SN - 1538-4101
SN - 1551-4005
ER -
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@article{2005_Sfeir,
author = {Agnel J. Sfeir and Jerry W. Shay and Woodring E. Wright},
title = {Fine-Tuning the Chromosome Ends: The Last Base of Human Telomeres},
journal = {Cell Cycle},
year = {2005},
volume = {4},
publisher = {Taylor & Francis},
month = {aug},
url = {https://doi.org/10.4161%2Fcc.4.11.2161},
number = {11},
pages = {1467--1470},
doi = {10.4161/cc.4.11.2161}
}
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Sfeir, Agnel J., et al. “Fine-Tuning the Chromosome Ends: The Last Base of Human Telomeres.” Cell Cycle, vol. 4, no. 11, Aug. 2005, pp. 1467-1470. https://doi.org/10.4161%2Fcc.4.11.2161.