Neutrophil-to-Lymphocyte Ratio Any Association with Metabolic Syndrome in Schizophrenia

To date, hematologic inflammation coefficients (HICs) have been considered as biological markers linking the functions of the immune, endocrine, and autonomous nervous systems. HICs are markers of immune abnormalities that accompany various pathologic conditions and, to a large extent, determine disease prognosis, survival time, and function. According to the results of a meta-analysis covering the results of examination of more than 168 thousand patients, it was found that the ratio of neutrophils to lymphocytes (NLR) is associated with higher levels in patients with metabolic syndrome and can potentially be used for early detection of this pathology. Given these facts, it seems reasonable to test the assumption of the role of HICs in the pathogenesis of psychiatric disorders, their participation in the mechanisms of development of comorbid conditions, or predicting the outcome and effects of therapy. In 2024, the team of the Bekhterev Center began to perform work under the state assignment of the Ministry of Health of the Russian Federation, the purpose of which was to develop and validate a model for predicting individual risks of metabolic disorders in patients with psychiatric disorders, on the basis of which interpretive software will be presented. The team of authors of this article focused on conducting a systematic review of publications to test this hypothesis.