Open Access
Open access
SAGE
International Journal of Biological Markers
,  volume 30 ,  issue 1 ,  pages 43-48

Relationship between NOB1 expression and prognosis of resected non-small cell lung cancer

Publication type: Journal Article
Publication date: 2015-01-01
SAGE
scimago Q2
wos Q3
SJR: 0.598
CiteScore: 3.8
Impact factor: 2.0
ISSN: 03936155, 17246008
DOI:  10.5301/jbm.5000120
PubMed ID:  25450647
Cancer Research
Oncology
Clinical Biochemistry
Pathology and Forensic Medicine
Abstract
Background

The aim of this study was to investigate the relationship between Nin one binding (NOB1) protein expression and prognosis for resected non-small cell lung cancer (NSCLC).

Methods

A prospective cohort of 70 consecutive patients with resected NSCLC was studied in 2009. Immunohistochemistry was used in the detection of NOB1 protein expression. Prognosis outcomes included overall survival (OS) and progression-free survival (PFS). The log-rank test and Cox hazard model were used to estimate the relationship between NOB1 expression and prognosis.

Results

In the 70 NSCLC tissue specimens, 14 (20%) stained -, 24 (34%) stained +, 21 (30%) stained ++ and 11 (16%) stained +++. The NOB1 high expression rate was 16%. NOB1 expression was significantly different between TMN stage (p=0.024) and lymph node metastasis (p=0.001), as well as histopathological grades (p=0.037). Median OS was 43 months (95% confidence interval [95% CI], 35-51 months), and median PFS was 37 months (95% CI, 25-49 months). OS and PFS were related to TMN stage and lymph node metastasis, as well as NOB1 expression (p<0.05). After adjustment for TMN stage and lymph node metastasis, the hazard ratio (HR) for high NOB1 expression was 1.7 (95% CI, 1.1-3.0, p=0.027) for OS, and 1.8 (95% CI, 1.3-3.7, p=0.031) for PFS.

Conclusions

Our results suggest that enhanced expression of NOB1 is related to poor overall survival and progression-free survival in patients with resected NSCLC.

Found 
Found 

Top-30

Journals

1
Current Drug Targets
Current Drug Targets, 1, 10%
Current Drug Targets
1 publication, 10%
Aging
Aging, 1, 10%
Aging
1 publication, 10%
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 1, 10%
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
1 publication, 10%
International Journal of Oncology
International Journal of Oncology, 1, 10%
International Journal of Oncology
1 publication, 10%
Oncology Letters
Oncology Letters, 1, 10%
Oncology Letters
1 publication, 10%
Oncology Reports
Oncology Reports, 1, 10%
Oncology Reports
1 publication, 10%
International Journal of Molecular Medicine
International Journal of Molecular Medicine, 1, 10%
International Journal of Molecular Medicine
1 publication, 10%
Scientific Reports
Scientific Reports, 1, 10%
Scientific Reports
1 publication, 10%
Biomedicine and Pharmacotherapy
Biomedicine and Pharmacotherapy, 1, 10%
Biomedicine and Pharmacotherapy
1 publication, 10%
Biomarkers in Medicine
Biomarkers in Medicine, 1, 10%
Biomarkers in Medicine
1 publication, 10%
1

Publishers

1
2
3
4
Spandidos Publications
Spandidos Publications, 4, 40%
Spandidos Publications
4 publications, 40%
Bentham Science Publishers Ltd.
Bentham Science Publishers Ltd., 1, 10%
Bentham Science Publishers Ltd.
1 publication, 10%
Impact Journals
Impact Journals, 1, 10%
Impact Journals
1 publication, 10%
Mary Ann Liebert
Mary Ann Liebert, 1, 10%
Mary Ann Liebert
1 publication, 10%
Springer Nature
Springer Nature, 1, 10%
Springer Nature
1 publication, 10%
Elsevier
Elsevier, 1, 10%
Elsevier
1 publication, 10%
, 1, 10%
1 publication, 10%
1
2
3
4
  • We do not take into account publications without a DOI.
  • Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
10
Share
Cite this
GOST |
Cite this
GOST Copy
Liu K. et al. Relationship between NOB1 expression and prognosis of resected non-small cell lung cancer // International Journal of Biological Markers. 2015. Vol. 30. No. 1. pp. 43-48.
GOST all authors (up to 50) Copy
Liu K., Chen H., Gu Ming M., You Q. Relationship between NOB1 expression and prognosis of resected non-small cell lung cancer // International Journal of Biological Markers. 2015. Vol. 30. No. 1. pp. 43-48.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.5301/jbm.5000120
UR - https://doi.org/10.5301/jbm.5000120
TI - Relationship between NOB1 expression and prognosis of resected non-small cell lung cancer
T2 - International Journal of Biological Markers
AU - Liu, Kun
AU - Chen, Hong-Lin
AU - Gu Ming, Ming
AU - You, Qing-Sheng
PY - 2015
DA - 2015/01/01
PB - SAGE
SP - 43-48
IS - 1
VL - 30
PMID - 25450647
SN - 0393-6155
SN - 1724-6008
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2015_Liu,
author = {Kun Liu and Hong-Lin Chen and Ming Gu Ming and Qing-Sheng You},
title = {Relationship between NOB1 expression and prognosis of resected non-small cell lung cancer},
journal = {International Journal of Biological Markers},
year = {2015},
volume = {30},
publisher = {SAGE},
month = {jan},
url = {https://doi.org/10.5301/jbm.5000120},
number = {1},
pages = {43--48},
doi = {10.5301/jbm.5000120}
}
MLA
Cite this
MLA Copy
Liu, Kun, et al. “Relationship between NOB1 expression and prognosis of resected non-small cell lung cancer.” International Journal of Biological Markers, vol. 30, no. 1, Jan. 2015, pp. 43-48. https://doi.org/10.5301/jbm.5000120.