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Physico-chemical properties of meso-tetrakis(p-methoxyphenyl)porphyrin (TMPP) incorporated into pluronicTM p-123 and f-127 polymeric micelles
Publication type: Journal Article
Publication date: 2014-07-07
scimago Q4
wos Q4
SJR: 0.194
CiteScore: 1.3
Impact factor: 0.7
ISSN: 01004042, 16787064
Abstract
The physicochemical properties (solubilization, structural organization and stability) of meso-tetrakis(p-methoxyphenyl)porphyrin (TMPP), a promising photosensitizer for photodynamic therapy, solubilized in polymeric micelles of tri-block copolymers PluronicTM P-123 and F-127, were studied. The formulations obtained by the solid dispersion method led to monomerization of TMPP in these copolymers. Solubility studies showed that P-123 solubilizes double the photosensitizer than F-127. The self-aggregation phenomenon was affected by the [TMPP]/[poloxamer] ratio and medium temperature. The decrease in the temperature of these systems promoted the formation of different kinds of TMPP aggregates intrinsically connected with the structural changes occurring in the micelles.
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Vilsinski B. H. et al. Physico-chemical properties of meso-tetrakis(p-methoxyphenyl)porphyrin (TMPP) incorporated into pluronicTM p-123 and f-127 polymeric micelles // Quimica Nova. 2014.
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Vilsinski B. H., Aparicio J. L., Pereira P. C., Fávaro S. L., Campanholi K. S., Gerola A. P., Tessaro A. L., Hioka N., Caetano W. Physico-chemical properties of meso-tetrakis(p-methoxyphenyl)porphyrin (TMPP) incorporated into pluronicTM p-123 and f-127 polymeric micelles // Quimica Nova. 2014.
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TY - JOUR
DO - 10.5935/0100-4042.20140273
UR - https://doi.org/10.5935/0100-4042.20140273
TI - Physico-chemical properties of meso-tetrakis(p-methoxyphenyl)porphyrin (TMPP) incorporated into pluronicTM p-123 and f-127 polymeric micelles
T2 - Quimica Nova
AU - Vilsinski, B H
AU - Aparicio, J L
AU - Pereira, P C
AU - Fávaro, S L
AU - Campanholi, K S
AU - Gerola, A P
AU - Tessaro, A L
AU - Hioka, N
AU - Caetano, W
PY - 2014
DA - 2014/07/07
PB - SciELO
SN - 0100-4042
SN - 1678-7064
ER -
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@article{2014_Vilsinski,
author = {B H Vilsinski and J L Aparicio and P C Pereira and S L Fávaro and K S Campanholi and A P Gerola and A L Tessaro and N Hioka and W Caetano},
title = {Physico-chemical properties of meso-tetrakis(p-methoxyphenyl)porphyrin (TMPP) incorporated into pluronicTM p-123 and f-127 polymeric micelles},
journal = {Quimica Nova},
year = {2014},
publisher = {SciELO},
month = {jul},
url = {https://doi.org/10.5935/0100-4042.20140273},
doi = {10.5935/0100-4042.20140273}
}