Multisensors based on electrolyte-gated organic field-effect transistors (EGOFETs) with aptamers as recognition elements: current state of research

The review gives a systematic analysis of published data devoted to multisensor technologies for manufacturing effective miniature devices capable of simultaneous accurate determination of several analytes and/or characteristics of biological fluids. The use of electrolyte-gated field-effect transistors as a biosensing platform is considered in detail. The devices based on these transistors demonstrate record-low limits of detection and are non-complicated for mass production. The use of electrolyte-gated organic field-effect transistors in combination with aptamers capable of specific binding to various analytes paves the way to innovations in early medical diagnostics (label-free biomarker detection). The most successful examples of multisensor devices using these transistors are presented, and the prospects of using aptamers as recognition elements in these devices are demonstrated.Bibliography — 154 references.