Microwave-Assisted Synthesis and Antitumor Activity of Salicyl Acyloxy Phosphonate Derivatives
Тип публикации: Journal Article
Дата публикации: 2015-01-13
scimago Q3
wos Q2
БС3
SJR: 0.393
CiteScore: 3
Impact factor: 2.2
ISSN: 02532786
Organic Chemistry
Краткое описание
Twelve new salicyl acyloxy phosphonate derivatives were synthesized via microwave-assisted reactions of sali- cylic acid with α-hydroxyphosphonate in DCC/DMAP. The structures of the products were confirmed by elemental analysis, IR, 1 H NMR and 13 C NMR data. The suitable synthetic conditions were as follows: in 15 mL of CH2Cl2 with power 800 W at room temperature for 3.5 h. The cytotoxic activities of all compounds on A-549, SGC-7901, HEp-2 and EC-109 in vitro were evaluated by using an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method, and some of them showed good antitumor activity. Among the active compounds, espectively, compound 2f had better inhibition effect on HEp-2 cells growth (IC50=(13.9±0.6) μmol/L), the IC50 values of compound 2k was (8.5±0.9) μmol/L against EC-109 cells, similar to cisplatin (IC50=(5.9±1.0) μmol/L). Keywords salicylic acid; α-hydroxyphosphonate; microwave irradiation; synthesis; antitumor activity
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Yang J. et al. Microwave-Assisted Synthesis and Antitumor Activity of Salicyl Acyloxy Phosphonate Derivatives // Chinese Journal of Organic Chemistry. 2015. Vol. 34. No. 12. p. 2566.
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Yang J., Sun Y., Che W., Li M., Li G., Song B. Microwave-Assisted Synthesis and Antitumor Activity of Salicyl Acyloxy Phosphonate Derivatives // Chinese Journal of Organic Chemistry. 2015. Vol. 34. No. 12. p. 2566.
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TY - JOUR
DO - 10.6023/cjoc201406026
UR - https://doi.org/10.6023/cjoc201406026
TI - Microwave-Assisted Synthesis and Antitumor Activity of Salicyl Acyloxy Phosphonate Derivatives
T2 - Chinese Journal of Organic Chemistry
AU - Yang, Jiaqiang
AU - Sun, Ying
AU - Che, Wanli
AU - Li, Minggang
AU - Li, Gang
AU - Song, Baoan
PY - 2015
DA - 2015/01/13
PB - Shanghai Institute of Organic Chemistry
SP - 2566
IS - 12
VL - 34
SN - 0253-2786
ER -
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@article{2015_Yang,
author = {Jiaqiang Yang and Ying Sun and Wanli Che and Minggang Li and Gang Li and Baoan Song},
title = {Microwave-Assisted Synthesis and Antitumor Activity of Salicyl Acyloxy Phosphonate Derivatives},
journal = {Chinese Journal of Organic Chemistry},
year = {2015},
volume = {34},
publisher = {Shanghai Institute of Organic Chemistry},
month = {jan},
url = {https://doi.org/10.6023/cjoc201406026},
number = {12},
pages = {2566},
doi = {10.6023/cjoc201406026}
}
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MLA
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Yang, Jiaqiang, et al. “Microwave-Assisted Synthesis and Antitumor Activity of Salicyl Acyloxy Phosphonate Derivatives.” Chinese Journal of Organic Chemistry, vol. 34, no. 12, Jan. 2015, p. 2566. https://doi.org/10.6023/cjoc201406026.