The strategy of combined application of nucleophilic aromatic substitution of hydrogen (S_N^H ) and transition metal-catalyzed cross-coupling reactions

Two powerful tools of organic synthesis, transition metal-catalyzed cross-coupling reactions and metal-free S_N^H reactions leading to nucleophilic displacement of hydrogen of the C(sp²)-H bond, have been combined into one convenient synthetic strategy. This idea has made it possible to obtain a wide variety of substituted azine derivatives, including push-pull systems, new biologically active compounds, organic semiconductors and sensor materials.