Open Access
Journal of Cancer, volume 12, issue 2, pages 387-396
Silencing of CASC8 inhibits non-small cell lung cancer cells function and promotes sensitivity to osimertinib via FOXM1
Jiang Xizi
1
,
Guan Jingqian
1
,
Xu Yitong
1
,
Ren Hongjiu
1
,
Jiang Jun
2
,
Wudu Muli
3
,
Wang Qiongzi
1
,
Su Hongbo
1
,
Zhang Yao
1
,
Zhang Bo
1
,
Zou Zifang
1
,
Hu Yujiao
1
,
Sun Xiaodan
1
,
Qiu Xue-shan
1
2
3
Department of Pathology, Basic Medical Sciences, Xinjiang Medical University, Urumqi, China.
|
Publication type: Journal Article
Publication date: 2020-12-16
PubMed ID:
33391435
Oncology
Abstract
In a meta-analysis, the long noncoding RNA cancer susceptibility candidate 8 (CASC8) was found to be a cancer susceptibility gene closely related to lung cancer, but its functions in lung cancer are unknown. In the Cancer Genome Atlas database, the expression of CASC8 was significantly higher in non-small cell lung cancer than in adjacent normal tissues, and high expression of CASC8 was associated with poor prognosis in patients with lung adenocarcinoma. Silencing CASC8 inhibited proliferation, migration, and invasion in non-small cell lung cancer cell lines. Silencing CASC8 also promoted sensitivity to osimertinib through Forkhead box M1 (FOXM1). Therefore, this pathway can be exploited in patients with lung cancer resistant to targeted therapies. Our study revealed for the first time that silencing CASC8 inhibited the proliferation, migration, and invasion of non-small cell lung cancer cells and promoted their sensitivity to osimertinib, suggesting that CASC8 is closely related to the occurrence and development of non-small cell lung cancer. This may provide insight into mechanisms of treatment for non-small cell lung cancer.
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Jiang X. et al. Silencing of CASC8 inhibits non-small cell lung cancer cells function and promotes sensitivity to osimertinib via FOXM1 // Journal of Cancer. 2020. Vol. 12. No. 2. pp. 387-396.
GOST all authors (up to 50)
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Jiang X., Guan J., Xu Y., Ren H., Jiang J., Wudu M., Wang Q., Su H., Zhang Y., Zhang B., Zou Z., Hu Y., Sun X., Qiu X. Silencing of CASC8 inhibits non-small cell lung cancer cells function and promotes sensitivity to osimertinib via FOXM1 // Journal of Cancer. 2020. Vol. 12. No. 2. pp. 387-396.
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TY - JOUR
DO - 10.7150/jca.47863
UR - https://doi.org/10.7150%2Fjca.47863
TI - Silencing of CASC8 inhibits non-small cell lung cancer cells function and promotes sensitivity to osimertinib via FOXM1
T2 - Journal of Cancer
AU - Jiang, Xizi
AU - Guan, Jingqian
AU - Xu, Yitong
AU - Ren, Hongjiu
AU - Jiang, Jun
AU - Wudu, Muli
AU - Wang, Qiongzi
AU - Su, Hongbo
AU - Zhang, Yao
AU - Zhang, Bo
AU - Zou, Zifang
AU - Hu, Yujiao
AU - Sun, Xiaodan
AU - Qiu, Xue-shan
PY - 2020
DA - 2020/12/16 00:00:00
PB - Ivyspring International Publisher
SP - 387-396
IS - 2
VL - 12
PMID - 33391435
SN - 1837-9664
ER -
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@article{2020_Jiang,
author = {Xizi Jiang and Jingqian Guan and Yitong Xu and Hongjiu Ren and Jun Jiang and Muli Wudu and Qiongzi Wang and Hongbo Su and Yao Zhang and Bo Zhang and Zifang Zou and Yujiao Hu and Xiaodan Sun and Xue-shan Qiu},
title = {Silencing of CASC8 inhibits non-small cell lung cancer cells function and promotes sensitivity to osimertinib via FOXM1},
journal = {Journal of Cancer},
year = {2020},
volume = {12},
publisher = {Ivyspring International Publisher},
month = {dec},
url = {https://doi.org/10.7150%2Fjca.47863},
number = {2},
pages = {387--396},
doi = {10.7150/jca.47863}
}
Cite this
MLA
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Jiang, Xizi, et al. “Silencing of CASC8 inhibits non-small cell lung cancer cells function and promotes sensitivity to osimertinib via FOXM1.” Journal of Cancer, vol. 12, no. 2, Dec. 2020, pp. 387-396. https://doi.org/10.7150%2Fjca.47863.