Open Access
eLife, volume 11
Boosting of cross-reactive antibodies to endemic coronaviruses by SARS-CoV-2 infection but not vaccination with stabilized spike
Andrew R. Crowley
1
,
Harini Natarajan
1
,
Andrew P Hederman
1
,
Carly A Bobak
1
,
Joshua A. Weiner
1
,
Wendy Wieland-Alter
2
,
Jiwon Lee
1
,
Evan M. Bloch
3
,
Aaron Ar Tobian
3
,
Andrew D. Redd
3, 4
,
Joel N. Blankson
3
,
Dana Wolf
5
,
Tessa Goetghebuer
6, 7
,
Arnaud Marchant
6
,
Ruth I Connor
2
,
Peter F. Wright
2
,
Margaret J. Ackerman
1
3
Johns Hopkins Asthma & Allergy Center, Johns Hopkins University School of Medicine
|
4
National Center for Biotechnology Information, National Institutes of Health
7
Pediatric Department, CHU St Pierre
|
Publication type: Journal Article
Publication date: 2022-03-15
General Biochemistry, Genetics and Molecular Biology
General Medicine
General Immunology and Microbiology
General Neuroscience
Abstract
Preexisting antibodies to endemic coronaviruses (CoV) that cross-react with SARS-CoV-2 have the potential to influence the antibody response to COVID-19 vaccination and infection for better or worse. In this observational study of mucosal and systemic humoral immunity in acutely infected, convalescent, and vaccinated subjects, we tested for cross-reactivity against endemic CoV spike (S) protein at subdomain resolution. Elevated responses, particularly to the β-CoV OC43, were observed in all natural infection cohorts tested and were correlated with the response to SARS-CoV-2. The kinetics of this response and isotypes involved suggest that infection boosts preexisting antibody lineages raised against prior endemic CoV exposure that cross-react. While further research is needed to discern whether this recalled response is desirable or detrimental, the boosted antibodies principally targeted the better-conserved S2 subdomain of the viral spike and were not associated with neutralization activity. In contrast, vaccination with a stabilized spike mRNA vaccine did not robustly boost cross-reactive antibodies, suggesting differing antigenicity and immunogenicity. In sum, this study provides evidence that antibodies targeting endemic CoV are robustly boosted in response to SARS-CoV-2 infection but not to vaccination with stabilized S, and that depending on conformation or other factors, the S2 subdomain of the spike protein triggers a rapidly recalled, IgG-dominated response that lacks neutralization activity.
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Crowley A. R. et al. Boosting of cross-reactive antibodies to endemic coronaviruses by SARS-CoV-2 infection but not vaccination with stabilized spike // eLife. 2022. Vol. 11.
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Natarajan H., Crowley A. R., Hederman A. P., Bobak C. A., Weiner J. A., Wieland-Alter W., Lee J., Bloch E. M., Tobian A. A., Redd A. D., Blankson J. N., Wolf D., Goetghebuer T., Marchant A., Connor R. I., Wright P. F., Ackerman M. J. Boosting of cross-reactive antibodies to endemic coronaviruses by SARS-CoV-2 infection but not vaccination with stabilized spike // eLife. 2022. Vol. 11.
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TY - JOUR
DO - 10.7554/elife.75228
UR - https://doi.org/10.7554/elife.75228
TI - Boosting of cross-reactive antibodies to endemic coronaviruses by SARS-CoV-2 infection but not vaccination with stabilized spike
T2 - eLife
AU - Crowley, Andrew R.
AU - Natarajan, Harini
AU - Hederman, Andrew P
AU - Bobak, Carly A
AU - Weiner, Joshua A.
AU - Wieland-Alter, Wendy
AU - Lee, Jiwon
AU - Bloch, Evan M.
AU - Tobian, Aaron Ar
AU - Redd, Andrew D.
AU - Blankson, Joel N.
AU - Wolf, Dana
AU - Goetghebuer, Tessa
AU - Marchant, Arnaud
AU - Connor, Ruth I
AU - Wright, Peter F.
AU - Ackerman, Margaret J.
PY - 2022
DA - 2022/03/15 00:00:00
PB - eLife Sciences Publications
VL - 11
SN - 2050-084X
SN - 2050-084X
ER -
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@article{2022_Crowley,
author = {Andrew R. Crowley and Harini Natarajan and Andrew P Hederman and Carly A Bobak and Joshua A. Weiner and Wendy Wieland-Alter and Jiwon Lee and Evan M. Bloch and Aaron Ar Tobian and Andrew D. Redd and Joel N. Blankson and Dana Wolf and Tessa Goetghebuer and Arnaud Marchant and Ruth I Connor and Peter F. Wright and Margaret J. Ackerman},
title = {Boosting of cross-reactive antibodies to endemic coronaviruses by SARS-CoV-2 infection but not vaccination with stabilized spike},
journal = {eLife},
year = {2022},
volume = {11},
publisher = {eLife Sciences Publications},
month = {mar},
url = {https://doi.org/10.7554/elife.75228},
doi = {10.7554/elife.75228}
}