THE TOXICITY OF 5-CHLORO-8-HYDROXY-3, 4-DIHYDRO-3-METHYL-ISOCOUMARIN-7-CARBOXYLIC ACID, A HYDROLYZATE OF OCHRATOXIN A
Publication type: Journal Article
Publication date: 1971-01-01
SJR: —
CiteScore: —
Impact factor: —
ISSN: 00215112, 18842828
PubMed ID:
5316313
General Biochemistry, Genetics and Molecular Biology
Abstract
Ochratoxin A can be hydrolyzed with a large amount of carboxypeptidase A to yield L-phenylalanine and an isocoumarin carboxylic acid. No hydrolytic effect was found, however, with the liver homogenate or the microsomal fraction of the rat. The toxicity of the hydrolyzate, isocoumarin carboxylic acid, was found to be much lower than that of ochratoxin A (LD50 16.96μg/egg) to the chicken embryo; it killed only 3 of 10 chicks when 100μg/egg was injected. The hypothesis that ochratoxin A should be hydrolyzed in the liver to exhibit the toxicity, therefore, does not seem to be justifiable.
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Total citations:
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Citations from 2024:
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GOST
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YAMAZAKI M. et al. THE TOXICITY OF 5-CHLORO-8-HYDROXY-3, 4-DIHYDRO-3-METHYL-ISOCOUMARIN-7-CARBOXYLIC ACID, A HYDROLYZATE OF OCHRATOXIN A // Japanese Journal of Medical Science and Biology. 1971. Vol. 24. No. 4. pp. 245-250.
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YAMAZAKI M., SUZUKI S., Sakakibara Y., MIYAKI K. THE TOXICITY OF 5-CHLORO-8-HYDROXY-3, 4-DIHYDRO-3-METHYL-ISOCOUMARIN-7-CARBOXYLIC ACID, A HYDROLYZATE OF OCHRATOXIN A // Japanese Journal of Medical Science and Biology. 1971. Vol. 24. No. 4. pp. 245-250.
Cite this
RIS
Copy
TY - JOUR
DO - 10.7883/yoken1952.24.245
UR - https://www.jstage.jst.go.jp/article/yoken1952/24/4/24_4_245/_article
TI - THE TOXICITY OF 5-CHLORO-8-HYDROXY-3, 4-DIHYDRO-3-METHYL-ISOCOUMARIN-7-CARBOXYLIC ACID, A HYDROLYZATE OF OCHRATOXIN A
T2 - Japanese Journal of Medical Science and Biology
AU - YAMAZAKI, Mikio
AU - SUZUKI, SHIGETOSHI
AU - Sakakibara, Yoko
AU - MIYAKI, Komei
PY - 1971
DA - 1971/01/01
PB - National Institute of Infectious Diseases
SP - 245-250
IS - 4
VL - 24
PMID - 5316313
SN - 0021-5112
SN - 1884-2828
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1971_YAMAZAKI,
author = {Mikio YAMAZAKI and SHIGETOSHI SUZUKI and Yoko Sakakibara and Komei MIYAKI},
title = {THE TOXICITY OF 5-CHLORO-8-HYDROXY-3, 4-DIHYDRO-3-METHYL-ISOCOUMARIN-7-CARBOXYLIC ACID, A HYDROLYZATE OF OCHRATOXIN A},
journal = {Japanese Journal of Medical Science and Biology},
year = {1971},
volume = {24},
publisher = {National Institute of Infectious Diseases},
month = {jan},
url = {https://www.jstage.jst.go.jp/article/yoken1952/24/4/24_4_245/_article},
number = {4},
pages = {245--250},
doi = {10.7883/yoken1952.24.245}
}
Cite this
MLA
Copy
YAMAZAKI, Mikio, et al. “THE TOXICITY OF 5-CHLORO-8-HYDROXY-3, 4-DIHYDRO-3-METHYL-ISOCOUMARIN-7-CARBOXYLIC ACID, A HYDROLYZATE OF OCHRATOXIN A.” Japanese Journal of Medical Science and Biology, vol. 24, no. 4, Jan. 1971, pp. 245-250. https://www.jstage.jst.go.jp/article/yoken1952/24/4/24_4_245/_article.