Open Access

Bioactive Materials, volume 7, pages 254-262

In vivo urinary compatibility of Mg-Sr-Ag alloy in swine model

Tie Di ¹

Hort N. ²

Chen Minfang ^{3, 4, 5}

Guan Renguo ¹

Ulasevich Sviatlana A ⁶

Skorb Ekaterina V. ⁶

Dapeng Zhao 赵大鹏 ⁷

Liu Yili ⁸

Holt-Torres Patricia ⁹

Amaro Rommie E ⁹

Hide authors affiliations Show authors affiliations: 9 affiliations

Engineering Research Center of Continuous Extrusion,Ministry of Education,Dalian Jiaotong University, Dalian 116028,China) |

Magnesium Innovation Center, Helmholtz-Zentrum Geesthacht, D-21502, Geesthacht, Germany |

School of Materials science and Engineering

⁴

TianJin University of Technology |

⁵

Tianjin 300384 China |

⁶

Infochemistry Scientific Center, ITMO University, St. Petersburg 192007, Russia |

⁷

College of Biology, Hunan University, 410082, Changsha, China. |

⁸

Department of Urology, China Medical University, Shenyang 110084, China |

⁹

Department of Bioengineering, Bourns College of Engineering, University of California at Riverside, CA, 92521, USA |

Publication type: Journal Article

Publication date: 2022-01-01

KeAi Communications Co.

Journal: Bioactive Materials

Quartile SCImago

Quartile WOS

Impact factor: 18.9

ISSN: 2452199X

DOI: 10.1016/j.bioactmat.2021.05.046

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Biotechnology

Biomaterials

Biomedical Engineering

Abstract

A biodegradable metallic ureteral stent with suitable mechanical properties and antibacterial activity remains a challenge. Here we reveal the scientific significance of a biodegradable Mg-Sr-Ag alloy with a favorable combination of balanced mechanical properties, adjustable indwelling time in urinary tract and evident antibacterial activity via in vivo experiments in a swine model. Attributed to the rheo-solidification process, equiaxial microstructure and significantly refined grains (average grain size: 27.1 μm) were achieved. Mg 17 Sr 2 and Mg 4 Ag were found as the primary precipitates in the matrix, due to which the alloy obtained ca. 111% increase in ultimate tensile strength in comparison to pure magnesium. Both the in vitro and in vivo results demonstrated the satisfactory biocompatibility of the alloy. Histological evaluation and bioindicators analysis suggested that there was no tissue damage, inflammation and lesions in the urinary system caused by the degradation process. The stent also improved the post-operative bladder functions viewed from the urodynamic results. Our findings highlight the potential of this alloy as antibacterial biodegradable urinary implant material. • Innovative biodegradable antibacterial Mg-Sr-Ag alloy. • In vivo study in pig ureter models. • Enhanced mechanical properties and adjustable indwelling time. • Outstanding urinary compatibility and evident antibacterial activity.

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Citations by journals

	1 2
Frontiers in Bioengineering and Biotechnology	Frontiers in Bioengineering and Biotechnology, 2, 25% Frontiers in Bioengineering and Biotechnology 2 publications, 25%
Current Opinion in Urology	Current Opinion in Urology, 1, 12.5% Current Opinion in Urology 1 publication, 12.5%
Journal of Alloys and Compounds	Journal of Alloys and Compounds, 1, 12.5% Journal of Alloys and Compounds 1 publication, 12.5%
Biocybernetics and Biomedical Engineering	Biocybernetics and Biomedical Engineering, 1, 12.5% Biocybernetics and Biomedical Engineering 1 publication, 12.5%
Biosensors and Bioelectronics	Biosensors and Bioelectronics, 1, 12.5% Biosensors and Bioelectronics 1 publication, 12.5%
Journal of Nanotheranostics	Journal of Nanotheranostics, 1, 12.5% Journal of Nanotheranostics 1 publication, 12.5%
ACS Applied Bio Materials	ACS Applied Bio Materials, 1, 12.5% ACS Applied Bio Materials 1 publication, 12.5%
	1 2

Citations by publishers

	1 2 3
Elsevier	Elsevier, 3, 37.5% Elsevier 3 publications, 37.5%
Frontiers Media S.A.	Frontiers Media S.A., 2, 25% Frontiers Media S.A. 2 publications, 25%
Wolters Kluwer Health	Wolters Kluwer Health, 1, 12.5% Wolters Kluwer Health 1 publication, 12.5%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 1, 12.5% Multidisciplinary Digital Publishing Institute (MDPI) 1 publication, 12.5%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 12.5% American Chemical Society (ACS) 1 publication, 12.5%
	1 2 3

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Tie D. et al. In vivo urinary compatibility of Mg-Sr-Ag alloy in swine model // Bioactive Materials. 2022. Vol. 7. pp. 254-262.

GOST all authors (up to 50) Copy

Tie D., Hort N., Chen M., Guan R., Ulasevich S. A., Skorb E. V., Dapeng Zhao 赵., Liu Y., Holt-Torres P., Amaro R. E. In vivo urinary compatibility of Mg-Sr-Ag alloy in swine model // Bioactive Materials. 2022. Vol. 7. pp. 254-262.

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RIS Copy

TY - JOUR

DO - 10.1016/j.bioactmat.2021.05.046

UR - https://doi.org/10.1016%2Fj.bioactmat.2021.05.046

TI - In vivo urinary compatibility of Mg-Sr-Ag alloy in swine model

T2 - Bioactive Materials

AU - Tie, Di

AU - Hort, N.

AU - Chen, Minfang

AU - Guan, Renguo

AU - Ulasevich, Sviatlana A

AU - Skorb, Ekaterina V.

AU - Dapeng Zhao, 赵大鹏

AU - Liu, Yili

AU - Holt-Torres, Patricia

AU - Amaro, Rommie E

PY - 2022

DA - 2022/01/01 00:00:00

PB - KeAi Communications Co.

SP - 254-262

VL - 7

SN - 2452-199X

ER -

BibTex

Cite this

BibTex Copy

@article{2022_Tie,

author = {Di Tie and N. Hort and Minfang Chen and Renguo Guan and Sviatlana A Ulasevich and Ekaterina V. Skorb and 赵大鹏 Dapeng Zhao and Yili Liu and Patricia Holt-Torres and Rommie E Amaro},

title = {In vivo urinary compatibility of Mg-Sr-Ag alloy in swine model},

journal = {Bioactive Materials},

year = {2022},

volume = {7},

publisher = {KeAi Communications Co.},

month = {jan},

url = {https://doi.org/10.1016%2Fj.bioactmat.2021.05.046},

pages = {254--262},

doi = {10.1016/j.bioactmat.2021.05.046}

}

Found error?

Publisher

KeAi Communications Co.

Journal

Bioactive Materials

Quartile SCImago

Quartile WOS

Impact factor

18.9

ISSN

2452199X (Print)

Labs

REC of Infochemistry

Profiles

Skorb, Ekaterina V