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Open access
Advanced NanoBiomed Research, volume 1, issue 5, pages 2000048

Self‐Assembled Liesegang Rings of Hydroxyapatite for Cell Culturing

Publication typeJournal Article
Publication date2021-03-23
Quartile SCImago
Quartile WOS
Impact factor3.2
ISSN26999307
Abstract
A novel method of 3D self-organization of patterns made of biomimetic hydroxyapatite (HA) in agar matrix is reported. The model system involves gradual ion diffusion and phase transitions of calcium phosphates. Herein, HA is precipitated for the first time in the agar gel matrix via single-diffusion gel growth technique to aggregate the inorganic Liesegang rings (LRs). These patterns are formed as periodic structures through precipitation reaction and arise during the reagent diffusion in a polymer matrix. The concentrations of these inner and outer electrolytes, as well as pH and temperature effects on the morphologies, periodicity, stability, and number of LRs, are studied. In this study, the periodic HA Liesegang ring structures (HA LRs) are fabricated via a diffusion-limited aggregation process. These patterns influence the C2C12 cell growth and allow to obtain the patterns formed by the cell tissue. This method can be prospective for the generation of 3D gradients in materials/3D gradient materials generation for studying the interface tissue engineering, systematic cell–biomaterial interaction, as well as for the fabrication of the stimuli-responsive gradients to control/mimic migration of cells during the wound healing.

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Eltantawy M. M. et al. Self‐Assembled Liesegang Rings of Hydroxyapatite for Cell Culturing // Advanced NanoBiomed Research. 2021. Vol. 1. No. 5. p. 2000048.
GOST all authors (up to 50) Copy
Eltantawy M. M., Belokon M. A., Belogub E. V., Ledovich O. I., Skorb E. V., Ulasevich S. A. Self‐Assembled Liesegang Rings of Hydroxyapatite for Cell Culturing // Advanced NanoBiomed Research. 2021. Vol. 1. No. 5. p. 2000048.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1002/anbr.202000048
UR - https://doi.org/10.1002%2Fanbr.202000048
TI - Self‐Assembled Liesegang Rings of Hydroxyapatite for Cell Culturing
T2 - Advanced NanoBiomed Research
AU - Eltantawy, Mervat M
AU - Belokon, Mikhail A
AU - Belogub, Elena V.
AU - Ledovich, Olesia I
AU - Skorb, Ekaterina V.
AU - Ulasevich, Sviatlana A
PY - 2021
DA - 2021/03/23 00:00:00
PB - Wiley
SP - 2000048
IS - 5
VL - 1
SN - 2699-9307
ER -
BibTex |
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BibTex Copy
@article{2021_Eltantawy,
author = {Mervat M Eltantawy and Mikhail A Belokon and Elena V. Belogub and Olesia I Ledovich and Ekaterina V. Skorb and Sviatlana A Ulasevich},
title = {Self‐Assembled Liesegang Rings of Hydroxyapatite for Cell Culturing},
journal = {Advanced NanoBiomed Research},
year = {2021},
volume = {1},
publisher = {Wiley},
month = {mar},
url = {https://doi.org/10.1002%2Fanbr.202000048},
number = {5},
pages = {2000048},
doi = {10.1002/anbr.202000048}
}
MLA
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MLA Copy
Eltantawy, Mervat M., et al. “Self‐Assembled Liesegang Rings of Hydroxyapatite for Cell Culturing.” Advanced NanoBiomed Research, vol. 1, no. 5, Mar. 2021, p. 2000048. https://doi.org/10.1002%2Fanbr.202000048.
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