Journal of Experimental Biology, volume 224, issue 16
The snake heart pacemaker is localized near the sinoatrial valve
4
Publication type: Journal Article
Publication date: 2021-08-15
Journal:
Journal of Experimental Biology
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 2.8
ISSN: 00220949, 14779145
Molecular Biology
Animal Science and Zoology
Physiology
Ecology, Evolution, Behavior and Systematics
Insect Science
Aquatic Science
Abstract
ABSTRACT
To provide the first description of the exact location of primary pacemaker of the squamate heart, we used sharp microelectrode impalements and optical mapping of isolated sinus venosus preparations from Burmese pythons. We located the dominant pacemaker site at the base of the right leaflet of the sinoatrial valve (SAV), but latent pacemakers were also identified in a circular region around the SAV. Acetylcholine (10−5 mol l−1) or noradrenaline (10−6 mol l−1) induced shifts of the leading pacemaker site to other points near the SAV. The ionic currents of most of the cardiomyocytes isolated enzymatically from the SAV region resembled those of typical working myocytes from the sinus venosus. However, seven cells lacked the background inward rectifier current (IK1) and had a time-dependent hyperpolarization-induced inward current identified as the ‘funny’ pacemaker current (If). Therefore, the region proximal to SAV demonstrates pacemaking activity and contains cells that resemble the electrophysiological properties of mammalian pacemaker myocytes.
Citations by journals
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Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
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Citations by publishers
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Abramochkin D. V. et al. The snake heart pacemaker is localized near the sinoatrial valve // Journal of Experimental Biology. 2021. Vol. 224. No. 16.
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Abramochkin D. V., Kuzmin V. S., Matchkov V. V., Kamensky A. A., Wang T. The snake heart pacemaker is localized near the sinoatrial valve // Journal of Experimental Biology. 2021. Vol. 224. No. 16.
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TY - JOUR
DO - 10.1242/jeb.242778
UR - https://doi.org/10.1242%2Fjeb.242778
TI - The snake heart pacemaker is localized near the sinoatrial valve
T2 - Journal of Experimental Biology
AU - Abramochkin, Denis V
AU - Kuzmin, Vladislav S.
AU - Matchkov, Vladimir V.
AU - Kamensky, A. A.
AU - Wang, Tobias
PY - 2021
DA - 2021/08/15 00:00:00
PB - The Company of Biologists
IS - 16
VL - 224
SN - 0022-0949
SN - 1477-9145
ER -
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@article{2021_Abramochkin,
author = {Denis V Abramochkin and Vladislav S. Kuzmin and Vladimir V. Matchkov and A. A. Kamensky and Tobias Wang},
title = {The snake heart pacemaker is localized near the sinoatrial valve},
journal = {Journal of Experimental Biology},
year = {2021},
volume = {224},
publisher = {The Company of Biologists},
month = {aug},
url = {https://doi.org/10.1242%2Fjeb.242778},
number = {16},
doi = {10.1242/jeb.242778}
}