Journal of Controlled Release, volume 340, pages 200-208
Barnase*Barstar-guided two-step targeting approach for drug delivery to tumor cells in vivo
Shramova E I
1
,
Shilova M V
1
,
Dzhalilova D S
,
Telegin G B
2
,
Proshkina G M
3
,
Ryabova A V
,
Zolotova N A
4
,
Publication type: Journal Article
Publication date: 2021-12-01
Journal:
Journal of Controlled Release
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 10.8
ISSN: 01683659, 18734995
Pharmaceutical Science
Abstract
For precise ligation of a targeting and cytotoxic moiety, the use of Barnase-Barstar pair as a molecular glue is proposed for the first time. Targeting was mediated through the use of a scaffold protein DARPin_9-29 specific for the human epidermal receptor 2 (HER2) antigen that is highly expressed on some types of cancer and Barnase*Barstar native bacterial proteins interacted with each other with Kd 10-14 M. The approach proposed consists of prelabeling a target tumor with hybrid protein DARPin-Barnase prior to administration of cytotoxic component-loaded liposomes that have Barstar covalently attached to their surface. Based on in vivo bioimaging we have proven that DARPin-based Barnase*Barstar-mediated pretargeting possesses precise tumor-targeting capability as well as antitumor activity leading to apparent tumor-growth inhibition of primary tumors and distant metastases in experimental animals. The results obtained indicate that the new system combining DARPin and Barnase*Barstar can be useful both for the drug development and for monitoring the response to treatment in vivo in preclinical studies.
Citations by journals
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Molecules
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1 publication, 25%
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Nanomedicine: Nanotechnology, Biology, and Medicine
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Nanomedicine: Nanotechnology, Biology, and Medicine
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Citations by publishers
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2
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 50%
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Elsevier
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Elsevier
1 publication, 25%
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Dove Medical Press
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Dove Medical Press
1 publication, 25%
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1
2
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Shramova E. I. et al. Barnase*Barstar-guided two-step targeting approach for drug delivery to tumor cells in vivo // Journal of Controlled Release. 2021. Vol. 340. pp. 200-208.
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Shramova E. I., Shilova M. V., Dzhalilova D. S., Telegin G. B., Deyev S. M., Proshkina G. M., Ryabova A. V., Zolotova N. A., Ryabova A., Dzhalilova D. Barnase*Barstar-guided two-step targeting approach for drug delivery to tumor cells in vivo // Journal of Controlled Release. 2021. Vol. 340. pp. 200-208.
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TY - JOUR
DO - 10.1016/j.jconrel.2021.11.001
UR - https://doi.org/10.1016%2Fj.jconrel.2021.11.001
TI - Barnase*Barstar-guided two-step targeting approach for drug delivery to tumor cells in vivo
T2 - Journal of Controlled Release
AU - Shramova, E I
AU - Shilova, M V
AU - Dzhalilova, D S
AU - Telegin, G B
AU - Deyev, S. M.
AU - Proshkina, G M
AU - Ryabova, A V
AU - Zolotova, N A
AU - Ryabova, Anastasia
AU - Dzhalilova, Dzhuliia
PY - 2021
DA - 2021/12/01 00:00:00
PB - Elsevier
SP - 200-208
VL - 340
SN - 0168-3659
SN - 1873-4995
ER -
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@article{2021_Shramova,
author = {E I Shramova and M V Shilova and D S Dzhalilova and G B Telegin and S. M. Deyev and G M Proshkina and A V Ryabova and N A Zolotova and Anastasia Ryabova and Dzhuliia Dzhalilova},
title = {Barnase*Barstar-guided two-step targeting approach for drug delivery to tumor cells in vivo},
journal = {Journal of Controlled Release},
year = {2021},
volume = {340},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016%2Fj.jconrel.2021.11.001},
pages = {200--208},
doi = {10.1016/j.jconrel.2021.11.001}
}