Brain Injury, volume 35, issue 4, pages 490-500
LIM kinase inhibitor T56-LIMKi protects mouse brain from photothrombotic stroke
Publication type: Journal Article
Publication date: 2021-02-01
Journal:
Brain Injury
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 1.9
ISSN: 02699052, 1362301X
Clinical Neurology
Developmental and Educational Psychology
Neuroscience (miscellaneous)
Abstract
ABSTRACT Primary Objective: In an ischemic stroke, the damage spreads from the infarction core to surrounding tissues. The present work was aimed at the search of effective neuroprotectors that restrict injury propagation. Research Design: We studied possible protective effects of inhibitors of protein kinases LIMK2 (T56-LIMKi), DYRK1A (harmine), and tryptophan hydroxylase (4-chlorophenylalanine) on infarction size and morphology of peri-infarct area after photothrombotic stroke (a model of ischemic stroke) in mouse brain. Methods and Procedures: Photothrombotic stroke was induced by laser irradiation of mouse cortex after administration of photosensitizer Bengal Rose, which does not penetrate cells and remains in blood vessels. Under light exposure, it induces vessel occlusion. Infarct volume and histological changes in the cerebral cortex were evaluated 3, 7 and 14 days after photothrombotic impact. Main Outcomes and Results: Harmine and 4-chlorophenylalanine did not influence infarct volume and morphology of peri-infarct area in the mouse brain cortex after photothrombotic stroke. However, LIMK2 inhibitor T56-LIMKi significantly reduced infarct volume 7 and 14 days after photothrombotic stroke. It also increased the percent of normochromic neurons and decreased the fraction of altered cortical cells (hypochromic, hyperchromic and pyknotic neurons). Conclusions: T56-LIMK2i may be considered as a promising anti-stroke agent.
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Citations by publishers
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Multidisciplinary Digital Publishing Institute (MDPI)
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 50%
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Demyanenko S. V., Uzdensky A. LIM kinase inhibitor T56-LIMKi protects mouse brain from photothrombotic stroke // Brain Injury. 2021. Vol. 35. No. 4. pp. 490-500.
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Demyanenko S. V., Uzdensky A. LIM kinase inhibitor T56-LIMKi protects mouse brain from photothrombotic stroke // Brain Injury. 2021. Vol. 35. No. 4. pp. 490-500.
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TY - JOUR
DO - 10.1080/02699052.2021.1879397
UR - https://doi.org/10.1080%2F02699052.2021.1879397
TI - LIM kinase inhibitor T56-LIMKi protects mouse brain from photothrombotic stroke
T2 - Brain Injury
AU - Uzdensky, Anatoly
AU - Demyanenko, Svetlana V
PY - 2021
DA - 2021/02/01 00:00:00
PB - Taylor & Francis
SP - 490-500
IS - 4
VL - 35
SN - 0269-9052
SN - 1362-301X
ER -
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@article{2021_Demyanenko,
author = {Anatoly Uzdensky and Svetlana V Demyanenko},
title = {LIM kinase inhibitor T56-LIMKi protects mouse brain from photothrombotic stroke},
journal = {Brain Injury},
year = {2021},
volume = {35},
publisher = {Taylor & Francis},
month = {feb},
url = {https://doi.org/10.1080%2F02699052.2021.1879397},
number = {4},
pages = {490--500},
doi = {10.1080/02699052.2021.1879397}
}
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MLA
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Demyanenko, Svetlana V., and Anatoly Uzdensky. “LIM kinase inhibitor T56-LIMKi protects mouse brain from photothrombotic stroke.” Brain Injury, vol. 35, no. 4, Feb. 2021, pp. 490-500. https://doi.org/10.1080%2F02699052.2021.1879397.