Small, volume 18, issue 4, pages 2103552
Drug‐Dependent Morphological Transitions in Spherical and Worm‐Like Polymeric Micelles Define Stability and Pharmacological Performance of Micellar Drugs
Lim Chaemin
1
,
Ramsey Jacob
1
,
Hwang Duhyeong
1
,
Teixeira S.
2, 3
,
Poon Chi Duen
4
,
Strauss Joshua D.
5
,
Rosen Elias P.
6
,
Kabanov A.A.
1, 7
1
Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA
|
2
Department of Chemical and Biomolecular Engineering University of Delaware 150 Academy Street Newark DE 19716 USA
|
3
NIST Center for Neutron Research National Institute of Standards and Technology 100 Bureau Drive Gaithersburg MD 20899 USA
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4
Research Computer Center University of North Carolina Chapel Hill Chapel Hill NC 27599 USA
|
5
Department of Biochemistry and Biophysics School of Medicine University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA
|
6
Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA
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Publication type: Journal Article
Publication date: 2021-11-28
General Chemistry
Biotechnology
General Materials Science
Biomaterials
Abstract
Significant advances in physicochemical properties of polymeric micelles enable optimization of therapeutic drug efficacy, supporting nanomedicine manufacturing and clinical translation. Yet, the effect of micelle morphology on pharmacological efficacy is not adequately addressed. This work addresses this gap by assessing pharmacological efficacy of polymeric micelles with spherical and worm-like morphologies. It is observed that poly(2-oxazoline)-based polymeric micelles can be elongated over time from a spherical structure to worm-like structure, with elongation influenced by several conditions, including the amount and type of drug loaded into the micelles. The role of different morphologies on pharmacological performance of drug loaded micelles against triple-negative breast cancer and pancreatic cancer tumor models is further evaluated. Spherical micelles accumulate rapidly in the tumor tissue while retaining large amounts of drug; worm-like micelles accumulate more slowly and only upon releasing significant amounts of drug. These findings suggest that the dynamic character of the drug-micelle structure and the micelle morphology play a critical role in pharmacological performance, and that spherical micelles are better suited for systemic delivery of anticancer drugs to tumors when drugs are loosely associated with the polymeric micelles.
Citations by journals
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1
2
3
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Pharmaceutics
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Pharmaceutics
3 publications, 9.68%
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Journal of Drug Delivery Science and Technology
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Journal of Drug Delivery Science and Technology
3 publications, 9.68%
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Nano Today
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Nano Today
2 publications, 6.45%
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Crystal Growth and Design
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Crystal Growth and Design
2 publications, 6.45%
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Biomacromolecules
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Biomacromolecules
2 publications, 6.45%
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Molecular Pharmaceutics
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Molecular Pharmaceutics
1 publication, 3.23%
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Journal of Pharmaceutical Investigation
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Journal of Pharmaceutical Investigation
1 publication, 3.23%
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International Journal of Pharmaceutics
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International Journal of Pharmaceutics
1 publication, 3.23%
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Colloids and Surfaces A: Physicochemical and Engineering Aspects
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Colloids and Surfaces A: Physicochemical and Engineering Aspects
1 publication, 3.23%
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Macromolecular Chemistry and Physics
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Macromolecular Chemistry and Physics
1 publication, 3.23%
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Macromolecular Bioscience
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Macromolecular Bioscience
1 publication, 3.23%
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Macromolecules
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Macromolecules
1 publication, 3.23%
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Physical Chemistry Chemical Physics
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Physical Chemistry Chemical Physics
1 publication, 3.23%
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Journal of Applied Polymer Science
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Journal of Applied Polymer Science
1 publication, 3.23%
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Journal of Controlled Release
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Journal of Controlled Release
1 publication, 3.23%
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Small
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Small
1 publication, 3.23%
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Advanced healthcare materials
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Advanced healthcare materials
1 publication, 3.23%
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Journal of Materials Chemistry B
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Journal of Materials Chemistry B
1 publication, 3.23%
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ACS Nano
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ACS Nano
1 publication, 3.23%
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International Journal of Biological Macromolecules
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International Journal of Biological Macromolecules
1 publication, 3.23%
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Colloid Journal
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Colloid Journal
1 publication, 3.23%
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Current Drug Delivery
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Current Drug Delivery
1 publication, 3.23%
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Biomaterials Advances
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Biomaterials Advances
1 publication, 3.23%
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Heliyon
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Heliyon
1 publication, 3.23%
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1
2
3
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Citations by publishers
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2
4
6
8
10
12
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Elsevier
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Elsevier
11 publications, 35.48%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
7 publications, 22.58%
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Wiley
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Wiley
5 publications, 16.13%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
3 publications, 9.68%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
2 publications, 6.45%
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Springer Nature
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Springer Nature
1 publication, 3.23%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 3.23%
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Bentham Science
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Bentham Science
1 publication, 3.23%
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2
4
6
8
10
12
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Lim C. et al. Drug‐Dependent Morphological Transitions in Spherical and Worm‐Like Polymeric Micelles Define Stability and Pharmacological Performance of Micellar Drugs // Small. 2021. Vol. 18. No. 4. p. 2103552.
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Lim C., Ramsey J., Hwang D., Teixeira S., Poon C. D., Strauss J. D., Rosen E. P., Klyachko N. L., Kabanov A. Drug‐Dependent Morphological Transitions in Spherical and Worm‐Like Polymeric Micelles Define Stability and Pharmacological Performance of Micellar Drugs // Small. 2021. Vol. 18. No. 4. p. 2103552.
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TY - JOUR
DO - 10.1002/smll.202103552
UR - https://doi.org/10.1002%2Fsmll.202103552
TI - Drug‐Dependent Morphological Transitions in Spherical and Worm‐Like Polymeric Micelles Define Stability and Pharmacological Performance of Micellar Drugs
T2 - Small
AU - Poon, Chi Duen
AU - Kabanov, A.A.
AU - Lim, Chaemin
AU - Ramsey, Jacob
AU - Hwang, Duhyeong
AU - Teixeira, S.
AU - Strauss, Joshua D.
AU - Rosen, Elias P.
AU - Klyachko, Natalia L.
PY - 2021
DA - 2021/11/28 00:00:00
PB - Wiley
SP - 2103552
IS - 4
VL - 18
SN - 1613-6810
SN - 1613-6829
ER -
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@article{2021_Lim,
author = {Chi Duen Poon and A.A. Kabanov and Chaemin Lim and Jacob Ramsey and Duhyeong Hwang and S. Teixeira and Joshua D. Strauss and Elias P. Rosen and Natalia L. Klyachko},
title = {Drug‐Dependent Morphological Transitions in Spherical and Worm‐Like Polymeric Micelles Define Stability and Pharmacological Performance of Micellar Drugs},
journal = {Small},
year = {2021},
volume = {18},
publisher = {Wiley},
month = {nov},
url = {https://doi.org/10.1002%2Fsmll.202103552},
number = {4},
pages = {2103552},
doi = {10.1002/smll.202103552}
}
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Lim, Chaemin, et al. “Drug‐Dependent Morphological Transitions in Spherical and Worm‐Like Polymeric Micelles Define Stability and Pharmacological Performance of Micellar Drugs.” Small, vol. 18, no. 4, Nov. 2021, p. 2103552. https://doi.org/10.1002%2Fsmll.202103552.
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