Nature Reviews Molecular Cell Biology, volume 17, issue 12, pages 756-770

Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression

Engreitz Jesse M ^{1, 2}

Ollikainen Noah ³

Guttman Mitchell ³

Hide authors affiliations Show authors affiliations: 3 affiliations

BROAD Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, USA |

Harvard–MIT Division of Health Sciences and Technology, MIT, Cambridge, USA |

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, USA |

Publication type: Journal Article

Publication date: 2016-10-26

Springer Nature

Journal: Nature Reviews Molecular Cell Biology

Quartile SCImago

Quartile WOS

Impact factor: 112.7

ISSN: 14710072, 14710080

DOI: 10.1038/nrm.2016.126

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Molecular Biology

Cell Biology

Abstract

Over the past decade, it has become clear that mammalian genomes encode thousands of long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological processes. Recent work studying the molecular mechanisms of several key examples — including Xist, which orchestrates X chromosome inactivation — has provided new insights into how lncRNAs can control cellular functions by acting in the nucleus. Here we discuss emerging mechanistic insights into how lncRNAs can regulate gene expression by coordinating regulatory proteins, localizing to target loci and shaping three-dimensional (3D) nuclear organization. We explore these principles to highlight biological challenges in gene regulation, in which lncRNAs are well-suited to perform roles that cannot be carried out by DNA elements or protein regulators alone, such as acting as spatial amplifiers of regulatory signals in the nucleus.

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	2 4 6 8 10 12
Frontiers in Genetics	Frontiers in Genetics, 11, 2.38% Frontiers in Genetics 11 publications, 2.38%
Nature Communications	Nature Communications, 10, 2.16% Nature Communications 10 publications, 2.16%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 9, 1.94% International Journal of Molecular Sciences 9 publications, 1.94%
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Cell Death and Disease	Cell Death and Disease, 8, 1.73% Cell Death and Disease 8 publications, 1.73%
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Nucleic Acids Research	Nucleic Acids Research, 6, 1.3% Nucleic Acids Research 6 publications, 1.3%
Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 5, 1.08% Proceedings of the National Academy of Sciences of the United States of America 5 publications, 1.08%
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Scientific Reports	Scientific Reports, 5, 1.08% Scientific Reports 5 publications, 1.08%
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Biochemical and Biophysical Research Communications	Biochemical and Biophysical Research Communications, 4, 0.86% Biochemical and Biophysical Research Communications 4 publications, 0.86%
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Non-coding RNA	Non-coding RNA, 3, 0.65% Non-coding RNA 3 publications, 0.65%
Frontiers in Immunology	Frontiers in Immunology, 3, 0.65% Frontiers in Immunology 3 publications, 0.65%
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Cell Death Discovery	Cell Death Discovery, 3, 0.65% Cell Death Discovery 3 publications, 0.65%
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Citations by publishers

	20 40 60 80 100 120
Springer Nature	Springer Nature, 109, 23.54% Springer Nature 109 publications, 23.54%
Elsevier	Elsevier, 71, 15.33% Elsevier 71 publications, 15.33%
Frontiers Media S.A.	Frontiers Media S.A., 44, 9.5% Frontiers Media S.A. 44 publications, 9.5%
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AME Publishing Company	AME Publishing Company, 7, 1.51% AME Publishing Company 7 publications, 1.51%
Hindawi Limited	Hindawi Limited, 6, 1.3% Hindawi Limited 6 publications, 1.3%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 5, 1.08% Proceedings of the National Academy of Sciences (PNAS) 5 publications, 1.08%
Mary Ann Liebert	Mary Ann Liebert, 5, 1.08% Mary Ann Liebert 5 publications, 1.08%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 4, 0.86% American Association for the Advancement of Science (AAAS) 4 publications, 0.86%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 4, 0.86% American Association for Cancer Research (AACR) 4 publications, 0.86%
Portland Press	Portland Press, 3, 0.65% Portland Press 3 publications, 0.65%
The Royal Society	The Royal Society, 3, 0.65% The Royal Society 3 publications, 0.65%
Pleiades Publishing	Pleiades Publishing, 3, 0.65% Pleiades Publishing 3 publications, 0.65%
Rockefeller University Press	Rockefeller University Press, 3, 0.65% Rockefeller University Press 3 publications, 0.65%
The Endocrine Society	The Endocrine Society, 2, 0.43% The Endocrine Society 2 publications, 0.43%
Impact Journals	Impact Journals, 2, 0.43% Impact Journals 2 publications, 0.43%
IOS Press	IOS Press, 2, 0.43% IOS Press 2 publications, 0.43%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 2, 0.43% American Society for Biochemistry and Molecular Biology 2 publications, 0.43%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 2, 0.43% Public Library of Science (PLoS) 2 publications, 0.43%
Federation of American Societies for Experimental Biology (FASEB)	Federation of American Societies for Experimental Biology (FASEB), 2, 0.43% Federation of American Societies for Experimental Biology (FASEB) 2 publications, 0.43%
American Chemical Society (ACS)	American Chemical Society (ACS), 2, 0.43% American Chemical Society (ACS) 2 publications, 0.43%
Thieme	Thieme, 2, 0.43% Thieme 2 publications, 0.43%
The American Association of Immunologists	The American Association of Immunologists, 1, 0.22% The American Association of Immunologists 1 publication, 0.22%
	20 40 60 80 100 120

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GOST Copy

Engreitz J. M. et al. Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression // Nature Reviews Molecular Cell Biology. 2016. Vol. 17. No. 12. pp. 756-770.

GOST all authors (up to 50) Copy

Engreitz J. M., Ollikainen N., Guttman M. Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression // Nature Reviews Molecular Cell Biology. 2016. Vol. 17. No. 12. pp. 756-770.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/nrm.2016.126

UR - https://doi.org/10.1038%2Fnrm.2016.126

TI - Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression

T2 - Nature Reviews Molecular Cell Biology

AU - Engreitz, Jesse M

AU - Ollikainen, Noah

AU - Guttman, Mitchell

PY - 2016

DA - 2016/10/26 00:00:00

PB - Springer Nature

SP - 756-770

IS - 12

VL - 17

SN - 1471-0072

SN - 1471-0080

ER -

BibTex |

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BibTex Copy

@article{2016_Engreitz,

author = {Jesse M Engreitz and Noah Ollikainen and Mitchell Guttman},

title = {Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression},

journal = {Nature Reviews Molecular Cell Biology},

year = {2016},

volume = {17},

publisher = {Springer Nature},

month = {oct},

url = {https://doi.org/10.1038%2Fnrm.2016.126},

number = {12},

pages = {756--770},

doi = {10.1038/nrm.2016.126}

}

MLA

Cite this

MLA Copy

Engreitz, Jesse M., et al. “Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression.” Nature Reviews Molecular Cell Biology, vol. 17, no. 12, Oct. 2016, pp. 756-770. https://doi.org/10.1038%2Fnrm.2016.126.

Found error?

Publisher

Springer Nature

Journal

Nature Reviews Molecular Cell Biology

Quartile SCImago

Quartile WOS

Impact factor

112.7

ISSN

14710072 (Print)
14710080 (Electronic)