Molecular Cell, volume 76, issue 3, pages 412-42200000

RNA Interactions Are Essential for CTCF-Mediated Genome Organization.

Ricardo Saldaña Meyer 1
Javier Rodriguez-Hernaez 2
Thelma Escobar 1
Mayilaadumveettil Nishana 2
Karina Jácome López 3
Elphège P. Nora 4, 5
Aristotelis Tsirigos 6, 7
Mayra Furlan-Magaril 3
Jane Skok 2
Danny Reinberg 1
Publication typeJournal Article
Publication date2019-11-01
Journal: Molecular Cell
Q1
Q1
SJR9.332
CiteScore26.0
Impact factor14.5
ISSN10972765, 10974164
Molecular Biology
Cell Biology
Abstract
The function of the CCCTC-binding factor (CTCF) in the organization of the genome has become an important area of investigation, but the mechanisms by which CTCF dynamically contributes to genome organization are not clear. We previously discovered that CTCF binds to large numbers of endogenous RNAs, promoting its self-association. In this regard, we now report two independent features that disrupt CTCF association with chromatin: inhibition of transcription and disruption of CTCF-RNA interactions through mutations of 2 of its 11 zinc fingers that are not required for CTCF binding to its cognate DNA site: zinc finger 1 (ZF1) or zinc finger 10 (ZF10). These mutations alter gene expression profiles as CTCF mutants lose their ability to form chromatin loops and thus the ability to insulate chromatin domains and to mediate CTCF long-range genomic interactions. Our results point to the importance of CTCF-mediated RNA interactions as a structural component of genome organization.
Found 
Found 

Top-30

Journals

2
4
6
8
10
12
14
Molecular Cell
14 publications, 6.7%
Nucleic Acids Research
12 publications, 5.74%
Nature Communications
9 publications, 4.31%
Nature Genetics
7 publications, 3.35%
Cell Reports
6 publications, 2.87%
Current Opinion in Genetics and Development
5 publications, 2.39%
International Journal of Molecular Sciences
4 publications, 1.91%
Frontiers in Cell and Developmental Biology
4 publications, 1.91%
Nature Reviews Genetics
4 publications, 1.91%
Proceedings of the National Academy of Sciences of the United States of America
3 publications, 1.44%
Genome Biology
3 publications, 1.44%
Biochemical Society Transactions
3 publications, 1.44%
Nature Structural and Molecular Biology
3 publications, 1.44%
Nature Reviews Molecular Cell Biology
3 publications, 1.44%
iScience
3 publications, 1.44%
Nucleus
3 publications, 1.44%
BioEssays
3 publications, 1.44%
Genes
2 publications, 0.96%
Nature Cell Biology
2 publications, 0.96%
BMC Genomics
2 publications, 0.96%
Journal of Biomedical Science
2 publications, 0.96%
Nature
2 publications, 0.96%
Oncogene
2 publications, 0.96%
Computational and Structural Biotechnology Journal
2 publications, 0.96%
Trends in Genetics
2 publications, 0.96%
Current Opinion in Cell Biology
2 publications, 0.96%
Cold Spring Harbor Symposia on Quantitative Biology
2 publications, 0.96%
Cancers
2 publications, 0.96%
Chromosoma
2 publications, 0.96%
2
4
6
8
10
12
14

Publishers

10
20
30
40
50
60
Springer Nature
59 publications, 28.23%
Elsevier
45 publications, 21.53%
Cold Spring Harbor Laboratory
35 publications, 16.75%
Oxford University Press
14 publications, 6.7%
MDPI
13 publications, 6.22%
Wiley
7 publications, 3.35%
Frontiers Media S.A.
6 publications, 2.87%
Portland Press
4 publications, 1.91%
Taylor & Francis
4 publications, 1.91%
Proceedings of the National Academy of Sciences (PNAS)
3 publications, 1.44%
Public Library of Science (PLoS)
2 publications, 0.96%
European Molecular Biology Organization
2 publications, 0.96%
Bioscientifica
2 publications, 0.96%
Ovid Technologies (Wolters Kluwer Health)
1 publication, 0.48%
SAGE
1 publication, 0.48%
American Society for Biochemistry and Molecular Biology
1 publication, 0.48%
American Society of Hematology
1 publication, 0.48%
Walter de Gruyter
1 publication, 0.48%
American Association for the Advancement of Science (AAAS)
1 publication, 0.48%
Research Square Platform LLC
1 publication, 0.48%
Pleiades Publishing
1 publication, 0.48%
The Russian Academy of Sciences
1 publication, 0.48%
10
20
30
40
50
60
  • We do not take into account publications without a DOI.
  • Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
  • Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
Share
Cite this
GOST |
Cite this
GOST Copy
Saldaña Meyer R. et al. RNA Interactions Are Essential for CTCF-Mediated Genome Organization. // Molecular Cell. 2019. Vol. 76. No. 3. pp. 412-42200000.
GOST all authors (up to 50) Copy
Saldaña Meyer R., Rodriguez-Hernaez J., Escobar T., Nishana M., Jácome López K., Nora E. P., Tsirigos A., Furlan-Magaril M., Skok J., Reinberg D. RNA Interactions Are Essential for CTCF-Mediated Genome Organization. // Molecular Cell. 2019. Vol. 76. No. 3. pp. 412-42200000.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/j.molcel.2019.08.015
UR - https://doi.org/10.1016/j.molcel.2019.08.015
TI - RNA Interactions Are Essential for CTCF-Mediated Genome Organization.
T2 - Molecular Cell
AU - Saldaña Meyer, Ricardo
AU - Rodriguez-Hernaez, Javier
AU - Escobar, Thelma
AU - Nishana, Mayilaadumveettil
AU - Jácome López, Karina
AU - Nora, Elphège P.
AU - Tsirigos, Aristotelis
AU - Furlan-Magaril, Mayra
AU - Skok, Jane
AU - Reinberg, Danny
PY - 2019
DA - 2019/11/01
PB - Elsevier
SP - 412-42200000
IS - 3
VL - 76
PMID - 31522988
SN - 1097-2765
SN - 1097-4164
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2019_Saldaña Meyer,
author = {Ricardo Saldaña Meyer and Javier Rodriguez-Hernaez and Thelma Escobar and Mayilaadumveettil Nishana and Karina Jácome López and Elphège P. Nora and Aristotelis Tsirigos and Mayra Furlan-Magaril and Jane Skok and Danny Reinberg},
title = {RNA Interactions Are Essential for CTCF-Mediated Genome Organization.},
journal = {Molecular Cell},
year = {2019},
volume = {76},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.molcel.2019.08.015},
number = {3},
pages = {412--42200000},
doi = {10.1016/j.molcel.2019.08.015}
}
MLA
Cite this
MLA Copy
Saldaña Meyer, Ricardo, et al. “RNA Interactions Are Essential for CTCF-Mediated Genome Organization..” Molecular Cell, vol. 76, no. 3, Nov. 2019, pp. 412-42200000. https://doi.org/10.1016/j.molcel.2019.08.015.
Found error?