Biochemical and Biophysical Research Communications, volume 586, pages 20-26
Curcumin by activation of adenosine A2A receptor stimulates protein kinase a and potentiates inhibitory effect of cangrelor on platelets
Publication type: Journal Article
Publication date: 2022-01-01
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 3.1
ISSN: 0006291X, 10902104
Biochemistry
Molecular Biology
Cell Biology
Biophysics
Abstract
Curcumin is a natural polyphenol derived from the turmeric plant (Curcuma longa) which exhibits numerous beneficial effects on different cell types. Inhibition of platelet activation by curcumin is well known, however molecular mechanisms of its action on platelets are not fully defined. In this study, we used laser diffraction method for analysis of platelet aggregation and Western blot for analysis of intracellular signaling mechanisms of curcumin effects on platelets. We identified two new molecular mechanisms involved in the inhibitory effects of curcumin on platelet activation. Firstly, curcumin by activation of adenosine A2A receptor stimulated protein kinase A activation and phosphorylation of Vasodilator-stimulated phosphoprotein. Secondly, we demonstrated that curcumin even at low doses, which did not inhibit platelet aggregation, potentiated inhibitory effect of ADP receptor P2Y12 antagonist cangrelor which partly could be explained by activation of adenosine A2A receptor.
Citations by journals
|
1
|
|
|
Marine Drugs
|
Marine Drugs
1 publication, 20%
|
|
Nutrients
|
Nutrients
1 publication, 20%
|
|
Biomedicines
|
Biomedicines
1 publication, 20%
|
|
PLoS ONE
|
PLoS ONE
1 publication, 20%
|
|
Biomedical and Pharmacology Journal
|
Biomedical and Pharmacology Journal, 1, 20%
Biomedical and Pharmacology Journal
1 publication, 20%
|
|
1
|
Citations by publishers
|
1
2
3
|
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
3 publications, 60%
|
|
Public Library of Science (PLoS)
|
Public Library of Science (PLoS)
1 publication, 20%
|
|
Oriental Scientific Publishing Company
|
Oriental Scientific Publishing Company, 1, 20%
Oriental Scientific Publishing Company
1 publication, 20%
|
|
1
2
3
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2022,2023],"ids":[0,0],"codes":[0,0],"imageUrls":["",""],"datasets":[{"label":"Citations number","data":[3,2],"backgroundColor":["#3B82F6","#3B82F6"],"percentage":["60","40"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Marine Drugs","Nutrients","Biomedicines","PLoS ONE","Biomedical and Pharmacology Journal"],"ids":[23709,3372,24421,24963,18335],"codes":[0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp",""],"datasets":[{"label":"","data":[1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[20,20,20,20,20],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Multidisciplinary Digital Publishing Institute (MDPI)","Public Library of Science (PLoS)","Oriental Scientific Publishing Company"],"ids":[202,344,6972],"codes":[0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp",""],"datasets":[{"label":"","data":[3,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":[60,20,20],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Rukoyatkina N. et al. Curcumin by activation of adenosine A2A receptor stimulates protein kinase a and potentiates inhibitory effect of cangrelor on platelets // Biochemical and Biophysical Research Communications. 2022. Vol. 586. pp. 20-26.
GOST all authors (up to 50)
Copy
Rukoyatkina N., Shpakova V., Bogoutdinova A., Kharazova A., Mindukshev I., Gambaryan S., Mindukshev I. V. Curcumin by activation of adenosine A2A receptor stimulates protein kinase a and potentiates inhibitory effect of cangrelor on platelets // Biochemical and Biophysical Research Communications. 2022. Vol. 586. pp. 20-26.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bbrc.2021.11.006
UR - https://doi.org/10.1016%2Fj.bbrc.2021.11.006
TI - Curcumin by activation of adenosine A2A receptor stimulates protein kinase a and potentiates inhibitory effect of cangrelor on platelets
T2 - Biochemical and Biophysical Research Communications
AU - Rukoyatkina, Natalia
AU - Shpakova, Valentina
AU - Bogoutdinova, Alina
AU - Kharazova, Alexandra
AU - Mindukshev, Igor
AU - Gambaryan, Stepan
AU - Mindukshev, I. V.
PY - 2022
DA - 2022/01/01 00:00:00
PB - Elsevier
SP - 20-26
VL - 586
SN - 0006-291X
SN - 1090-2104
ER -
Cite this
BibTex
Copy
@article{2022_Rukoyatkina,
author = {Natalia Rukoyatkina and Valentina Shpakova and Alina Bogoutdinova and Alexandra Kharazova and Igor Mindukshev and Stepan Gambaryan and I. V. Mindukshev},
title = {Curcumin by activation of adenosine A2A receptor stimulates protein kinase a and potentiates inhibitory effect of cangrelor on platelets},
journal = {Biochemical and Biophysical Research Communications},
year = {2022},
volume = {586},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016%2Fj.bbrc.2021.11.006},
pages = {20--26},
doi = {10.1016/j.bbrc.2021.11.006}
}