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Cancer Communications, volume 42, issue 2, pages 83-87

Lipid droplets: could they be involved in cancer growth and cancer–microenvironment communications?

Schwartsburd Polina ¹

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Institute of Theoretical and Experimental Biophysics Russian Academy of Sciences Pushchino Moscow Region 142290 Russia |

Publication type: Journal Article

Publication date: 2022-01-13

Springer Nature

Journal: Cancer Communications

Quartile SCImago

Quartile WOS

Impact factor: 16.2

ISSN: 25233548, 09553541

DOI: 10.1002/cac2.12257

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PubMed ID: 35029069

Cancer Research

Oncology

Abstract

Common characteristics of tumor cells include the reprogramming of glucose and lipid metabolism, especially the upregulation of glycolysis and lipogenesis accompanied by the accumulation of lipid droplets (LDs) predominantly in aggressive cancer cells and their microenvironment, such as the cancer cells and microenvironment in Zajdela ascites hepatoma (ZAH) [1, 2]. This work analyzed the hypothesis that LD-rich malignant cells gain an advantage for their survival, growth, and immune escape through cancer-derived LDs actingwithinmalignant cells and their microenvironment in a synergistic manner. The effect can be amplified at hypoxia/acidosis in the tumor microenvironment, which stimulates mainly the accumulation of dispersed LDs in tumor cells [3, 4]. Our research, however, found that intracellular LDs and their orderly packed clusters appeared in dividing ZAH cells, whereas surface LD-containing vesicles in ZAH cells acted as a source of extracellular LDs. Could these LDs be involved in cancer unrestricted proliferation and cancer-induced metabolic communications with a microenvironment participating in local immunosuppressive response? Critical analysis of the literature supports a positive answer to these questions and to the proposed hypothesis.

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International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 25% International Journal of Molecular Sciences 1 publication, 25%
Journal of Molecular Structure	Journal of Molecular Structure, 1, 25% Journal of Molecular Structure 1 publication, 25%
Molecules	Molecules, 1, 25% Molecules 1 publication, 25%
	1

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Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 2, 50% Multidisciplinary Digital Publishing Institute (MDPI) 2 publications, 50%
Elsevier	Elsevier, 1, 25% Elsevier 1 publication, 25%
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Schwartsburd P. Lipid droplets: could they be involved in cancer growth and cancer–microenvironment communications? // Cancer Communications. 2022. Vol. 42. No. 2. pp. 83-87.

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Schwartsburd P. Lipid droplets: could they be involved in cancer growth and cancer–microenvironment communications? // Cancer Communications. 2022. Vol. 42. No. 2. pp. 83-87.

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