ACS applied materials & interfaces, volume 10, issue 17, pages 14367-14377
Ceria Nanoparticles-Decorated Microcapsules as a Smart Drug Delivery/Protective System: Protection of Encapsulated P. pyralis Luciferase
Popov Anton L.
1
,
Popova Nelli
1
,
Gould David J
2
,
Sukhorukov Gleb B.
1, 4
,
Ivanov Vladimir K.
5, 6
3
Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv D0368, Ukraine
|
Publication type: Journal Article
Publication date: 2018-04-10
Journal:
ACS applied materials & interfaces
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 9.5
ISSN: 19448244, 19448252
General Materials Science
Abstract
The design of novel, effective drug delivery systems is one of the most promising ways to improve the treatment of socially important diseases. This article reports on an innovative approach to the production of composite microcontainers (microcapsules) bearing advanced protective functions. Cerium oxide (CeO2) nanoparticles were incorporated into layer-by-layer polyelectrolyte microcapsules as a protective shell for an encapsulated enzyme (luciferase of Photinus pyralis), preventing its oxidation by hydrogen peroxide, the most abundant type of reactive oxygen species (ROS). The protective effect depends on CeO2 loading in the shell: at a low concentration, CeO2 nanoparticles only scavenge ROS, whereas a higher content leads to a decrease in access for both ROS and the substrate to the enzyme in the core. By varying the nanoparticle concentration in the microcapsule, it is possible to control the level of core shielding, from ROS filtering to complete blocking. A comprehensive analysis of microcapsules by transmission electron microscopy, scanning electron microscopy, atomic force microscopy, confocal laser scanning microscopy, and energy-dispersive X-ray spectroscopy techniques was carried out. Composite microcapsules decorated with CeO2 nanoparticles and encapsulated luciferase were shown to be easily taken up by rat B-50 neuronal cells; they are nontoxic and are able to protect cells from the oxidative stress induced by hydrogen peroxide. The approach demonstrated that the active protection of microencapsulated substances by CeO2 nanoparticles can be used in the development of new drug delivery and diagnostic systems.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Popov A. L. et al. Ceria Nanoparticles-Decorated Microcapsules as a Smart Drug Delivery/Protective System: Protection of Encapsulated P. pyralis Luciferase // ACS applied materials & interfaces. 2018. Vol. 10. No. 17. pp. 14367-14377.
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Popov A. L., Popova N., Gould D. J., Shcherbakov A. B., Sukhorukov G. B., Ivanov V. K. Ceria Nanoparticles-Decorated Microcapsules as a Smart Drug Delivery/Protective System: Protection of Encapsulated P. pyralis Luciferase // ACS applied materials & interfaces. 2018. Vol. 10. No. 17. pp. 14367-14377.
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TY - JOUR
DO - 10.1021/acsami.7b19658
UR - https://doi.org/10.1021%2Facsami.7b19658
TI - Ceria Nanoparticles-Decorated Microcapsules as a Smart Drug Delivery/Protective System: Protection of Encapsulated P. pyralis Luciferase
T2 - ACS applied materials & interfaces
AU - Popova, Nelli
AU - Ivanov, Vladimir K.
AU - Popov, Anton L.
AU - Gould, David J
AU - Shcherbakov, Alexander B.
AU - Sukhorukov, Gleb B.
PY - 2018
DA - 2018/04/10 00:00:00
PB - American Chemical Society (ACS)
SP - 14367-14377
IS - 17
VL - 10
SN - 1944-8244
SN - 1944-8252
ER -
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@article{2018_Popov,
author = {Nelli Popova and Vladimir K. Ivanov and Anton L. Popov and David J Gould and Alexander B. Shcherbakov and Gleb B. Sukhorukov},
title = {Ceria Nanoparticles-Decorated Microcapsules as a Smart Drug Delivery/Protective System: Protection of Encapsulated P. pyralis Luciferase},
journal = {ACS applied materials & interfaces},
year = {2018},
volume = {10},
publisher = {American Chemical Society (ACS)},
month = {apr},
url = {https://doi.org/10.1021%2Facsami.7b19658},
number = {17},
pages = {14367--14377},
doi = {10.1021/acsami.7b19658}
}
Cite this
MLA
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Popov, Anton L., et al. “Ceria Nanoparticles-Decorated Microcapsules as a Smart Drug Delivery/Protective System: Protection of Encapsulated P. pyralis Luciferase.” ACS applied materials & interfaces, vol. 10, no. 17, Apr. 2018, pp. 14367-14377. https://doi.org/10.1021%2Facsami.7b19658.