Virology

GottikhLab unites employees and students of various departments of Lomonosov Moscow State University, who study the features of virus replication, the interaction of viral and cellular proteins, and also try to transform this knowledge into new approaches to the control of viral infections. The main targets are HIV-1 and SARS-CoV-2.

We are looking for antiviral drugs.

We study the molecular mechanisms of resistance of cultivated plants to adverse environmental factors.

Main areas of scientific activity: Analysis of long-term B-cell immunological memory after SARS-CoV-2 infection; Analysis of neutralizing antibodies after vaccination/SARS-CoV-2 infection; Antigenic cartography of SARS-CoV-2 variants; Reprogramming of memory B cells in order to create producers of human therapeutic monoclonal antibodies; Creation of a seedless systems for in vitro stimulation of B lymphocytes using multimerized proteins containing the CD40L receptor domain; Transduction of human B lymphocytes using adenoassociated viruses of various serotypes; Study of the features of the B-cell response to the major allergen of birch pollen Bet v 1; Study of the relationship of allergic sensitization with serum IgE levels; Study of human leukocyte differentiation antigens, in particular, the pathways of phosphorylation of CD45 associated protein (CD45-AP) and its role in the activation of human lymphocytes

Genetic editing, viral hepatitis, drug delivery, intracellular immunity, epitranscriptomics

The COLLECTION OF MICROORGANISMS OF THE PASTEUR Research Institute OF EPIDEMIOLOGY AND MICROBIOLOGY of the Pasteur Research Institute of Epidemiology and Microbiology has been collecting, studying the properties and storing pathogenic microorganisms since the 70s of the twentieth century. The collection represents a highly valuable conserved gene pool of microorganisms isolated by employees of microbiological and virological laboratories. The Micros Collective Use Center is based on the Pasteur Research Institute of Microbiology and Epidemiology. The laboratories included in the structure have modern high-precision equipment and qualified personnel for the collection, identification and collection of strains of microorganisms of 3 and 4 pathogenicity groups.

Studying the genetic diversity of pig viruses in Russia

The laboratory was established in 2022 as part of the national project "Science and Universities". The main research area of the laboratory is the study of oncolytic viruses as agents for virotherapy of oncological diseases and the development of an antitumor oncolytic drug based on viruses. Currently, the laboratory focuses on the study of oncolytic strains of the genus Orthoavulavirus, namely, the Newcastle disease virus. A significant place in the laboratory's research is devoted to establishing the mechanisms of oncolytic action of viruses - their direct cytotoxic effect on tumor cells and indirect antitumor immunomodulatory effect, as well as possible antiangiogenic effects of virotherapy.

Development of innovative medicines, conducting preclinical and registration studies of antiviral, immunostimulating and cytotoxic activity of chemotherapy drugs.