Radiochemistry

Directions of the laboratory's work: 1) Improvement of spent nuclear fuel (SNF) reprocessing processes using oxidation and nitriding operations 2) Creation of new approaches to the processing of waste containing plastic, ion exchange resins, cellulose, toxic organic compounds 3) Development of processes for the localization of radioactive iodine 4) Research in the field of inorganic chemistry of actinides

The laboratory is actively working on the study of atomic tritium reactions and the production of tritium-labeled compounds, which are used to study various physico-chemical and biochemical processes.

The laboratory is engaged in determining the dose of ionizing radiation accumulated in various materials, as well as the development of materials for individual dosimetry.

Laboratory No.135 is engaged in the synthesis of macrocyclic and acyclic chelators, as well as a comprehensive study of their complexing properties with respect to medical metal cations in order to create diagnostic and therapeutic radiopharmaceuticals based on them. For targeted delivery of the radionuclide complex to the affected area, bifunctional chelating agents and their conjugates with vector molecules such as peptides, antibodies and nanoparticles are being developed. Our research suggests an integrated approach to solving the task, starting from the design of the structure of chelators, the development of methods for their synthesis and ending with a complete analysis of their complexing characteristics. To do this, we use methods of HPLC, mass spectrometry, NMR spectroscopy, X-ray diffraction analysis, quantum chemical calculations, potentiometric and spectrophotometric titration, as well as radionuclide labeling and stability analyses in vitro and in vivo. In the course of our research, we identify the advantages and disadvantages of new ligands and identify patterns that affect their ability to bind a particular metal cation. The results obtained make it possible to expand the range of possible new radiopharmaceuticals for the diagnosis and treatment of oncological diseases, which is currently extremely relevant.

analysis of environmental objects for content and physicochemical forms of radionuclides study of regularities and migration pathways of technogenic radionuclides in surface and underground biogeocenoses, including marine areas of the Russian Arctic development of new, highly effective, and express methods for the radiochemical analysis of environmental objects development of methods for control and purification of aquatic environments from radioactive substances and other ecotoxicants impurities