Physiology

The laboratory carries out fundamental and applied research in the field of normal physiology, psychophysiology, behavioral physiology and sports.

The MEG Center is engaged in research of the human brain using the only multichannel installation for magnetoencephalography in Russia - a method close to EEG, but providing significantly higher spatial resolution.

The study of cell receptor systems and the processes of transduction of external stimuli

Development of methods for the diagnosis and therapy of human and animal diseases, research in the field of radiobiology, conducting research using radioisotope methods.

To study platelet apoptosis as a predictor of adverse outcomes after surgical myocardial revascularization. The use of a helium-oxygen breathing mixture (heliox) in the early postoperative period as an early rehabilitation and cardioprotection.

Gravitational physiology, physiology of the sensorimotor system, space medicine, neurorehabilitation, motor control, prevention of negative effects of spaceflight

The work of the laboratory is devoted to a comprehensive study of the features of physiological reactions and endogenous mechanisms of the unique resistance of winter-sleeping (hibernating) animals (Yakut ground squirrels) to the effects of extreme environmental factors.

The main interest of the laboratory is to study the molecular mechanisms that ensure the performance of specialized functions of various types of CNS cells under normal and pathological conditions.

Research in the field of psychoneuroendocrinology is actively developing. Hormonal status disorders are known to underlie behavioral and cognitive deficits in aging, Alzheimer's disease, menopausal and premenstrual syndrome in women. Based on the study of the interaction between the endocrine and neurotransmitter systems, drugs are being developed that combine the properties of hormones (estrogen, androgen) and neurotropic agents (agonist-antagonist of M1 acetylcholine receptors, 1A and 2A serotonin receptors, D1 and D2 dopamine receptors). The use of substances of this kind will make it possible to eliminate disorders in both the endocrine and neurotransmitter systems simultaneously, preventing the formation of a "vicious" circle. Molecular pathogenetic studies have shown violations of neuroendocrine transmission (steroid, thyroid hormones, biogenic amines and their metabolites), intracellular signal transduction (SC2 cascade) and receptor expression (1A- and 2A-serotonin receptors, 17b-estradiol) in cognitive disorders associated with estrogen deficiency and aging. An important section of psychoneuroendocrinological research is the study of the non-hormonal effects of hormones and hormone-like substances. Thus, pharmacological analysis using liberins, the tropic hormones of the pituitary gland, revealed the hormonal components of dependence on alcohol, opiates, psychostimulants and other narcogens. The possibility of blocking addictive behavior in animals by intrastructural administration of antagonists of corticoliberin, ghrelin, orexin and substance P, i.e. peptide hormones modulating emotional and motivational components of behavior, is shown. On this basis, a platform has been formulated for the creation of pharmacological drugs with an anti-narcotic effect.