Institute of Biostructure and Bioimaging

NucleobaseNano

Chemistry of coordination compounds Spectroscopy Neuroscience

R-3D10E-00000-WU49V

0000-0001-6065-2367

35580154100

Head of Laboratory

Giovanni N Roviello

Publications

150

Citations

3 177

h-index

R-3D10E-00000-WU49V

0000-0001-6065-2367

35580154100

Authorization required.

Lab website

Nanomedicine based on structures formed by different nucleobases-containing systems like DNA, G4 DNA, RNA and nucleopeptides. We also study metal complexes, small molecules, synthetic amino acida and peptides

Molecular docking
Spectroscopy
Circular dichroism spectroscopy

Giovanni Roviello 🥼 🤝

Head of Laboratory

Research directions

New Drug delivery systems

Self assembly of nucleoamino acids, peptides and other molecules into nanosystems for innovative drug delivery systems

G4 DNA

Quadruplex DNA investigated for anticancer strategies

Neurodrug development

We are investigating new molecules systems able to modulate the aggregation of biomolecules like amyloid peptide and G4C2 nucleic acids involved in neurodegenerative diseases like Alzheimer disease, ALS and FTD

Forest bathing

We are designing new methods employing plant-emitted volatile organic biogenic compounds (VOCs) as immunomodulatory compounds for human disease prevention and therapy

Plant metabolites

We are investigated different plant metabolites for their potential applications in therapy of cancer and other socially-relevant pathologies

Publications and patents

SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and other Drugs for the Treatment of the New Coronavirus

Current Medicinal Chemistry (Q2), 2020, Citations: 225

Evaluating the biological properties of synthetic 4-nitrophenyl functionalized benzofuran derivatives with telomeric DNA binding and antiproliferative activities

International Journal of Biological Macromolecules (Q1), 2019, Citations: 47

Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine-based compounds on β-amyloid aggregation

Chemico-Biological Interactions (Q1), 2021, Citations: 42

Self-assembly of thyminyl l-tryptophanamide (TrpT) building blocks for the potential development of drug delivery nanosystems

Journal of Nanostructure in Chemistry (Q1), 2023, Citations: 18

Novel insights on nucleopeptide binding: A spectroscopic and in silico investigation on the interaction of a thymine-bearing tetrapeptide with a homoadenine DNA

Journal of Molecular Liquids (Q1), 2022, Citations: 14

Directing in Vitro Selection towards G‐quadruplex‐forming Aptamers to Inhibit HMGB1 Pathological Activity

Angewandte Chemie - International Edition (Q1), 2024, Citations: 10

Found

Method for sequencing nucleic acids and analogues thereof

Enrico Bucci, Maria Moccia, Domenica Musumeci, Carlo Pedone, Giovanni Roviello, Roberto Sapio, Margherita Valente

WO2006131249A2, 2006

Partners

Lab address

Via Tommaso De Amicis, 95, 80145 Napoli NA, Италия

Authorization required.