Laboratory of Nanobiomaterials and Bioeffectors for the diagnosis of socially significant diseases

The laboratory was established in 2019 as part of the national project "Science and Universities". The main areas of work are Synthesis of new types of polyhedral and cellular coordination compounds; modeling and experimental study of their antiviral, antitumor and antifibrillogenic activity; creation of "topological drugs" for transcriptional inhibition of enzymes, biochemical and medical samples, antifibrillogenic, antiviral and antitumor compounds as well as nature-like catalytic systems for the most important chemical processes and hybrid organo-inorganic and magnetic materials based on these compounds. The most significant results are data on the occurrence of chirality of clathrochelates caused by their binding to chiral organic molecules and protein macromolecules. For the first time, induced chirality and, consequently, the appearance of circular dichroism spectra of metal cellular complexes due to their supramolecular binding to optically active organic molecules and to protein macromolecules has been discovered. Such complexes are promising molecular chiral samples for establishing the structure of macromolecules of these proteins and studying their conformational transitions. The first stable "classical" iron(I) complex has been obtained and structurally characterized. It has demonstrated high chemical stability in highly acidic media. Methods for obtaining pseudomacrobicyclic cobalt complexes with a closoborate counterion have been developed. The first high-spin cobalt(II) pseudoclathrochelate with a volumetric closoborate antidianion formed by crosslinking with a solvent molecule as an H-acceptor was obtained. The complex is characterized by a high anisotropy of the magnetic susceptibility tensor and has the properties of a monionic monomolecular magnet. Its H-linked solvent molecule undergoes substitution under the action of stronger hydrogen bond acceptors. This compound is a promising reactive precursor for the creation of new molecular magnetic materials. Methods for the synthesis of new hybrid carboranoclathrochelates have been developed. Propargylamine clathrochelates of iron(II) were obtained by nucleophilic substitution of chloroclathrochelate precursors under the action of an excess of propargylamine. Their further functionalization using the 1,3-dipolar cycloaddition reaction led to the first hybrid carborane clathrochelates with a labile spacer fragment between their polyhedral centers.