Publications
115
Citations
915
h-index
15
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Laboratory staff synthesize nanostructured materials to study their properties for further application in the fields of sensorics and theranostics. In particular, molecular and nanostructured generators of reactive oxygen species (ROS) are being developed and studied in the laboratory. An experimental and theoretical study of the effect of low-frequency low-intensity ultrasound on the optical and photochemical properties of ROS generators is also being conducted. Another area of the laboratory is the development and research of magnetic nanoparticles and magneto–luminescent nanocomposites based on luminescent quantum semiconductor systems and carbon dots. The laboratory is also developing and researching luminescent hybrid nanostructures based on graphene and quantum dots for sensors. Circular dichroism spectroscopy and magnetic circular dichroism spectroscopy are used to study the electronic transitions of nanostructured materials and polyatomic molecules. Confocal laser microscopy with stationary and time resolution is actively used in the laboratory to study nanoparticles and hybrid materials based on them, as well as to create holographic diffraction and sensor elements.
- Absorption spectroscopy
- Luminescence
- Luminescence lifetime
- Scanning electron microscopy (SEM)
- Confocal microscopy
- IR spectroscopy
- Circular dichroism spectroscopy
- Dynamic light scattering (DLS)
Peter Parfenov
Researcher
Anastasiya Bulgakova
Research Engineer
Mariya Kovova
Research Engineer
Vasiliy Kabaruhin
Research intern
Maxim Rider
PhD student
Semen Domarev
PhD student
Tatiana Filimonova
Student
Maria Yaroslavova
Student
Margarita Borovskaia
Student
Filip Tyutyunnikov
Student
Research directions
In situ growth of metal oxide nanostructures on a 2D matrix for advanced photocatalytic applications
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This project develops and investigates the properties of TMO/MXene nanocomposites made of Transition Metal Oxide (TMO) and two-dimensional titanium carbide (Ti3C2 MXene) for applications in the field of heterogeneous catalysis. The aim of the project is to synthesize nanocomposites that will be used for environmental restoration, in particular, for selective photodegradation of aquatic pollutants, as well as for use in energy (H2 production) through photocatalytic splitting of water.
Photoactivatable nanocomposite systems for minimally invasive glioblastoma therapy under the control of magnetic resonance imaging
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The development of new MRI contrasting nanostructured composites demonstrating effective generation of reactive oxygen species under the influence of electromagnetic radiation and focused ultrasound for minimally invasive therapy of glioblastoma with in situ MRI control includes: 1. Development of MRI contrasting nanostructured composites based on magnetic LF and ROS photosensitizers; 2. Identification of patterns of occurrence of local sources of photoexcitation under the action of ultrasound of a given frequency and intensity and the effectiveness of their use to activate ROS photosensitizers; 3. Establishment of the dependence of the MRI contrast of nanostructured composites on their architecture; 4. Demonstration of the functionality of composites in vitro, ex vivo and in vivo
Magnetic luminescent nanocomposites for biomedical applications
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Magnetically luminescent nanocomposites were obtained by single-stage microwave synthesis using precursors of carbon dots and magnetic nanoparticles. Composites are interesting for their properties, such as tunable fluorescence with a quantum yield of up to 28%, high photostability and low cytotoxicity. The luminescent response of carbon dots allows them to be used as biomarkers, and magnetic susceptibility can be applied to local hyperthermia of cells under the influence of an alternating magnetic field.
Creation of hybrid structures based on filamentous nanocrystals and carbon dots for nanophotonics elements
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The mechanisms of interaction and effective injection of charge carriers from luminescent nanoparticles to filamentous nanocrystals (nanowiskers) with a large surface area are investigated. Under certain conditions, a nanowisker can act as a resonator, enhancing the luminescence of particles decorating its surface. Such hybrid structures can be used to produce photosensitive sensors and sensors.
Laser microscopy of dynamics of luminescent nanostructures
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1) Modeling and experimental investigation of the dynamics of photoinduced luminescence inhomogeneity in a mixture of nanoparticles of various sizes. 2) Modeling and experimental investigation of the spatial distribution of the luminescence intensity of nanocrystals in a colloidal solution with a photoinduced change in the diffusion coefficient. 3) Creation of a photosensitive photopolymer material with luminescent nanocrystals for recording holographic diffraction and sensor elements. 4)Holographic recording and laser scanning microscopy of periodic structures with luminescent nanocrystals. 5) Investigation of the motion of quantum dots in spatially inhomogeneous (cellular and imitating) systems by holographic relaxometry and luminescence restoration (sFRAP, stripe Fluorescence Recovery After Photobleaching). 6) Modeling the redistribution of luminescent nanoparticles in space during interference (holographic) and direct recording by a laser beam in a photopolymer.
Spectroscopy of circular and magnetic circular dichroism of nanostructures and composites based on them
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Spectroscopy of magnetic circular dichroism of superparamagnetic iron oxide nanoparticles (SPIONS) and composites based on them. Investigation of aggregation conditions, optical and magneto-optical properties of tetrapyrrole compounds (pheophorbide A and its analogues, including the zinc complex of tetraphenylporphine and its non-metallic analog). MCD spectra are more informative than absorption spectra in identifying electronic transitions corresponding to overlapping absorption bands. It is possible to identify degenerate transitions, despite the fact that the absorption spectra themselves in the ultraviolet and visible regions do not allow this. The MCD spectra provide additional information about the contribution of the magnetic dipole moment, which is determined by a change in the intensity of the MCD signal, compared with absorption spectra in which only the contribution of the electric dipole moment prevails.
Sensors based on hybrid Graphene structures/Quantum dots
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Creation and investigation of the dependence of photophysical and photovoltaic properties of a photochemical sensor based on graphene nanofibers and triple quantum dots for the detection of nitrogen-containing gases and volatile markers of certain diseases. Manufacturing and identification of dependences of photophysical and photoelectric properties of a biosensor based on nanostructured carbon, triple quantum dots and phthalocyanines/tetrapyrazineporphyrazines for the preventive detection of cardiovascular diseases. The use of a hybrid system based on graphene and semiconductor nanocrystals is the most popular solution for achieving high efficiency conversion of absorbed energy into a useful signal of a final photovoltaic device. Creating counters based on Arduino and developing software (Python/C++) for working with sensors. The outstanding photophysical and photovoltaic properties of the graphene/quantum dot hybrid structure make it possible to create multiparameter sensors based on them.
Photo- and sonodynamic therapy of diseases and its main mechanisms
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Development and study of nanostructured and molecular generators of reactive oxygen species (ROS) for photodynamic and sonodynamic therapy of tumors. The study of the photophysical properties of tetrapyrrole compounds and their use as generators of chemically active singlet oxygen. Experimental and theoretical studies of the effect of low-intensity ultrasound with a frequency of 20 kHz on the optical and catalytic properties of molecular and nanostructured stabilizers for ROS generation
Publications and patents
Антон Сергеевич Букатин, Тигран Арменакови Вартанян, Игорь Аркадьевич Гладских, Далер Рауфович Дададжанов, Антонина Ивановна Дададжанова, Ксения Киричек, Анна Олеговна Орлова, Анастасия Алексеевна Сапунова, Никита Александрович Торопов
RU2781351C1,
2022
Кирилл Игоревич Аннас, Владимир Николаевич Борисов, Любовь Николаевна Бородина, Андрей Викторович Вениаминов, Анна Олеговна Орлова, Иван Алексеевич Резник
RU2752026C1,
2021
Александр Васильевич Баранов, Екатерина Петровна Колесова, Евгений Валерьевич Кунделев, Владимир Григорьевич Маслов, Анна Олеговна Орлова, Иван Алексеевич Резник, Анатолий Валентинович Федоров
RU2675918C1,
2018
Александр Васильевич Баранов, Юлия Александровна Громова, Алексей Юрьевич Дубовик, Екатерина Петровна Колесова, Владимир Григорьевич Маслов, Максим Андреевич Миропольцев, Анна Олеговна Орлова, Иван Алексеевич Резник, Анатолий Валентинович Фёдоров, Сергей Александрович Черевков
RU2646419C1,
2018
Александр Васильевич Баранов, Анастасия Константиновна Вишератина, Юлия Александровна Громова, Юрий Кузьмич Гунько, Владимир Григорьевич Маслов, Анна Олеговна Орлова, Анатолий Валентинович Фёдоров
RU2629390C2,
2017
Александр Васильевич Баранов, Юрий Кузьмич Гунько, Владимир Григорьевич Маслов, Мария Викторовна Мухина, Анна Олеговна Орлова, Анатолий Валентинович Федоров
RU2583097C2,
2016
Анвар Саматович Баймуратов, Александр Васильевич Баранов, Михаил Александрович Баранов, Кирилл Вадимович Богданов, Андрей Викторович Вениаминов, Галина Николаевна Виноградова, Юлия Александровна Громова, Виктор Валерьевич Захаров, Михаил Юрьевич Леонов, Александр Петрович Литвин, Ирина Владимировна Мартыненко, Владимир Григорьевич Маслов, Мария Викторовна Мухина, Анна Олеговна Орлова, Пётр Сергеевич Парфёнов, et. al.
RU2533209C1,
2014
Анвар Саматович Баймуратов, Александр Васильевич Баранов, Михаил Александрович Баранов, Кирилл Вадимович Богданов, Андрей Викторович Вениаминов, Галина Николаевна Виноградова, Юлия Александровна Громова, Виктор Валерьевич Захаров, Михаил Юрьевич Леонов, Александр Петрович Литвин, Ирина Владимировна Мартыненко, Владимир Григорьевич Маслов, Мария Викторовна Мухина, Анна Олеговна Орлова, Пётр Сергеевич Парфёнов, et. al.
RU2532690C1,
2014
Анвар Саматович Баймуратов, Александр Васильевич Баранов, Михаил Александрович Баранов, Кирилл Вадимович Богданов, Андрей Викторович Вениаминов, Галина Николаевна Виноградова, Юлия Александровна Громова, Виктор Валерьевич Захаров, Михаил Юрьевич Леонов, Александр Петрович Литвин, Ирина Владимировна Мартыненко, Владимир Григорьевич Маслов, Мария Викторовна Мухина, Анна Олеговна Орлова, Пётр Сергеевич Парфёнов, et. al.
RU2530238C2,
2014
Анвар Саматович Баймуратов, Александр Васильевич Баранов, Михаил Александрович Баранов, Кирилл Вадимович Богданов, Андрей Викторович Вениаминов, Галина Николаевна Виноградова, Юлия Александровна Громова, Виктор Валерьевич Захаров, Михаил Юрьевич Леонов, Александр Петрович Литвин, Ирина Владимировна Мартыненко, Владимир Григорьевич Маслов, Мария Викторовна Мухина, Анна Олеговна Орлова
RU2522735C1,
2014
Анвар Саматович Баймуратов, Александр Васильевич Баранов, Михаил Александрович Баранов, Кирилл Вадимович Богданов, Андрей Викторович Вениаминов, Галина Николаевна Виноградова, Юлия Александровна Громова, Виктор Валерьевич Захаров, Михаил Юрьевич Леонов, Александр Петрович Литвин, Ирина Владимировна Мартыненко, Владимир Григорьевич Маслов, Мария Викторовна Мухина, Анна Олеговна Орлова, Пётр Сергеевич Парфёнов, et. al.
RU2522902C1,
2014
Анвар Саматович Баймуратов, Александр Васильевич Баранов, Михаил Александрович Баранов, Кирилл Вадимович Богданов, Андрей Викторович Вениаминов, Галина Николаевна Виноградова, Юлия Александровна Громова, Марина Сергеевна Губанова, Виктор Валерьевич Захаров, Михаил Юрьевич Леонов, Александр Петрович Литвин, Владимир Григорьевич Маслов, Мария Викторовна Мухина, Анна Олеговна Орлова, Пётр Сергеевич Парфёнов, et. al.
RU2504430C1,
2014
Александр Васильевич Баранов (RU), Александр Васильевич Баранов, Андрей Викторович Вениаминов (RU), Андрей Викторович Вениаминов, Галина Николаевна Виноградова (RU), Галина Николаевна Виноградова, Надежда Михайловна Германова (RU), Надежда Михайловна Германова, Юлия Александровна Громова (RU), Юлия Александровна Громова, Марина Сергеевна Губанова (RU), Марина Сергеевна Губанова, Алексей Николаевич Катрузов (RU), Алексей Николаевич Катрузов, Анатолий Александрович Крашенинников (RU), et. al.
RU2456579C1,
2012
Александр Васильевич Баранов (RU), Александр Васильевич Баранов, Андрей Викторович Вениаминов (RU), Андрей Викторович Вениаминов, Галина Николаевна Виноградова (RU), Галина Николаевна Виноградова, Юрий Михайлович Воронин (RU), Юрий Михайлович Воронин, Надежда Михайловна Германова (RU), Надежда Михайловна Германова, Владимир Георгиевич Маслов (RU), Владимир Георгиевич Маслов, Анна Олеговна Орлова (RU), Анна Олеговна Орлова, Петр Сергеевич Парфенов (RU), et. al.
RU2414696C2,
2010
Partners
Lab address
Санкт-Петербург, Биржевая линия, д. 14
Authorization required.